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Product Information

I. Basic Properties & Chemical Structure

Semax is a synthetically derived heptapeptide compound with the molecular formula C₃₇H₅₁N₉O₁₀S and a molecular weight of ~813.93 Da. Its structure is based on the 4-10 amino acid fragment of adrenocorticotropic hormone (ACTH; Met-Glu-His-Phe-Pro-Gly-Pro), with a C-terminal Pro-Gly-Pro tripeptide extension to enhance stability. Key properties include:

• Appearance: White to off-white lyophilized powder

• Solubility: Slightly soluble in water (>2 mg/mL), freely soluble in DMSO

• Purity: ≥97% (RP-HPLC-verified)

• Storage: Store dry at -20°C protected from light; avoid repeated freeze-thaw cycles.

II. Mechanism of Action & Bioactivity

1. Neurotrophic Regulation:
   Rapidly upregulates expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus, promoting neuronal survival and synaptic plasticity.

2. Neurotransmitter Modulation:
   Enhances serotonergic and dopaminergic pathway activity, regulating learning, memory, and stress responses.

3. Immune & Vascular Modulation:
   In ischemia models, regulates immune-related genes (e.g., immunoglobulins, chemokines) and promotes angiogenesis-associated gene expression, reducing inflammatory damage.

4. Antioxidant & Anti-hypoxic Effects:
   Inhibitssynthesis and lipid peroxidation, enhancing cellular tolerance to hypoxic stress.

III. Research Applications

1. Neuroprotection Studies

   • Reduces neuronal apoptosis and improves functional recovery in cerebral ischemia/reperfusion models (e.g., rat pMCAO model).

   • Protects mitochondrial function and maintains calcium homeostasis in oxidative stress models (e.g., glutamate toxicity).

   • 1. Cognitive Function Research

        • Enhances spatial memory consolidation in animal models (e.g., Morris water maze test).

        • Modulates cholinergic neuron activity and increases acetylcholinesterase efficacy.

     2. Neuro-Immune Interactions

        • Reveals regulatory effects on immune cell migration and antibody synthesis via transcriptomic analysis, serving as a tool for neuroimmune disease research.

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     IV. Usage Guidelines

     • Intended Use: For in vitro or animal research only. Not approved for human use, clinical applications, or commercial production.

     • Handling Protocol:

       • Reconstitute using sterile deionized water or buffer (recommended concentration ≥100 μg/mL).

       • Solutions should be prepared fresh and used within ≤72 hours at 4°C; for long-term storage, add carrier protein (e.g., 0.1% BSA) and freeze.

     • Biosafety:

       • In vivo studies require ethical approval and compliance with animal welfare regulations.

       • Dispose of waste as biohazardous material (e.g., degrade with 10% ).

     Solution Stability Reference

     Solvent System	Stability (-20℃)	Critical Notes
     DMSO stock	>12 months	Aliquot; avoid freeze-thaw cycles
     PBS buffer	≤72 hours	Prepare fresh; store at 4°C
     Serum-containing medium	≤48 hours	Avoid reduced activity due to protein binding

Company Introduction

csxj Technology Co., Ltd. is an innovative technology enterprise specializing in the field of weight management and metabolic health. We are dedicated to the R&D, production, and supply of high-quality solutions based on cutting-edge biotechnology for the global market, with core expertise in GLP-1-related products and high-purity active ingredients. Leveraging robust scientific capabilities and a stringent quality management system, we consistently deliver safe, efficient weight management and metabolic products and materials to meet diverse client needs. Driven by technological innovation and a customer-centric approach, we collaborate with partners to advance the health industry and empower global users in achieving healthier lifestyles.

Introduction to transportation
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