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67567-26-4

Name: 67567-26-4
Brand: Orient
SKU: pr2512171213
Price: 4 USD
Availability: InStock

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CAS No.:

67567-26-4

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

Product Name:	4-Bromo-2,6-difluoroaniline
Synonyms:	2,6-DIFLUORO-4-BROMOANILINE;4-BROMO-2,6-DIFLUOROANILINE;4-BROMO-2,6-DIFLUOROANILINE 99%;BUTTPARK 22\07-66;4-Bromo-2,6-difluoroaniline ,98%;4-Bromo-2,6-difluoro;2,6-difluro-4-broMoaniline;(4-BroMo-2,6-difluorophenyl)aMine
CAS:	67567-26-4
MF:	C6H4BrF2N
MW:	208
EINECS:	642-485-7
Product Categories:	Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Amines;C2 to C6;Nitrogen Compounds
Mol File:	67567-26-4.mol

4-Bromo-2,6-difluoroaniline Chemical Properties

Melting point	63-65 °C (lit.)
Boiling point	188.2±35.0 °C(Predicted)
density	1.788±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Powder
pka	1.11±0.10(Predicted)
color	Brown
InChI	InChI=1S/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
InChIKey	BFQSQUAVMNHOEF-UHFFFAOYSA-N
SMILES	C1(N)=C(F)C=C(Br)C=C1F
CAS DataBase Reference	67567-26-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36-36/37/39-22
WGK Germany	3
HazardClass	IRRITANT
HS Code	29214200

MSDS Information

4-Bromo-2,6-difluoroaniline Usage And Synthesis

Chemical Properties	Off-white crystalline
Uses	4-Bromo-2,6-difluoroaniline was used in synthesis of: ammonium 5-bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, fluorogenic derivatizating reagent for the determination of aminothiols by HPLC olefin tolanes 1-(4-amino-3,5-difluoro)-2-(4-butyloxyphenyl)ethyne 4′′-n-butyloxy-3,5-difluoroterphenyl-4-amine 4-(3-methylbut-1-yn-3-ol)-2,6-difluoroaniline
Uses	4-Bromo-2,6-difluoroaniline is used in the preparation of potent, VEGF receptor tyrosine kinase inhibitors.
Synthesis	5509-65-9 67567-26-4 b) Preparation of Intermediate 2: Dissolve 2,6-difluoroaniline (3.0 g, 22.56 mmol) in acetic acid (10 mL). Bromine (1.2 mL) was slowly added dropwise to the above solution. The reaction mixture was stirred at room temperature for 15 minutes. After the reaction was completed, the solvent was evaporated under reduced pressure. The residue was neutralized with aqueous sodium carbonate and the aqueous phase was subsequently extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give Intermediate 2 in 92% yield.
References	[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 4, p. 1544 - 1547 [2] Angew. Chem., 2016, vol. 128, # 4, p. 1569 - 1573,5 [3] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5326 - 5333 [4] Patent: WO2006/15985, 2006, A1. Location in patent: Page/Page column 54 [5] Patent: US6716491, 2004, B2

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

4-Bromo-2,6-difluoroaniline

Other Name:

4-BROMO-2,6-DIFLUOROANILINE;2,6-DIFLUORO-4-BROMOANILINE;BUTTPARK 22\07-66;4-BROMO-2,6-DIFLUOROANILINE 99%;4-Bromo-2,6-difluoroaniline ,98%;4-Bromo-2,6-difluoro;2,6-difluro-4-broMoaniline;(4-BroMo-2,6-difluorophenyl)aMine

CAS No.:

67567-26-4

Molecular Formula:

C6H4BrF2N

InChIKeys:

BFQSQUAVMNHOEF-UHFFFAOYSA-N

Molecular Weight:

208

Exact Mass:

206.949509

DSSTox ID:

DTXSID60346178

HScode:

2921420090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

2.1

Appearance:

Brown Crystalline Powder

Density:

1.8±0.1 g/cm3

Melting Point:

63-65 °C(lit.)

Boiling Point:

188.2°C at 760 mmHg

Flash Point:

67.6±25.9 °C

Refractive Index:

1.570

See More 4-Bromo-2,6-difluoroaniline Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-Bromo-2,6-difluoroaniline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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67567-26-4

Product Description

Seller Information

First aid measures

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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