Name | Sunifiram |
CAS number | 314728-85-3 |
Description | Sunifiram is a synthetic compound belonging to a novel class of nootropic agents known as the racetam analogs, with the CAS Registry Number 314728-85-3. |
Structural formula |  |
Molecular Formula | C14H18N2O2 |
Molecular Weight | 246.3 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Sunifiram is a synthetic compound belonging to a novel class of nootropic agents known as the racetam analogs, with the CAS Registry Number 314728-85-3. Its molecular structure is a low molecular weight derivative of piracetam, simplified to a pyrrolidine core connected to a carbonyl-containing side chain. This structural simplification was designed to enhance potency and cognitive-enhancing effects compared to its predecessor while maintaining a favorable safety profile. It is typically encountered as a white or off-white crystalline powder in research settings.
The precise pharmacological mechanism of action for sunifiram is not fully elucidated but is believed to differ from classical racetams. Research suggests its potent cognitive effects are primarily mediated through the modulation of glutamatergic neurotransmission, specifically as a positive allosteric modulator of the AMPA subtype of glutamate receptors. This action enhances fast excitatory synaptic transmission, which is critical for learning and memory processes. Additionally, it may influence cholinergic and monoaminergic systems, and has been shown to increase the expression of neurotrophic factors in animal models.
The primary interest and application for sunifiram lie within the domain of nootropic research. It is studied for its potential to enhance cognitive functions such as memory formation, learning capacity, and attention. Preclinical studies in rodents have demonstrated significant improvements in memory retention and cognitive performance in various behavioral models at very low doses. Due to these findings, it has been marketed as a "smart drug" or dietary supplement for cognitive enhancement, although such use is based on limited human data and occurs outside of formal medical regulation.
From a biochemical perspective, sunifiram exhibits very high potency, with active doses in the microgram to low milligram range in animal studies, which is significantly lower than traditional racetams. Its pharmacokinetic properties in humans are not well-characterized, but its low molecular weight suggests potential for good absorption. In research contexts, it is typically administered orally or via intraperitoneal injection to assess its effects on cognitive and behavioral endpoints.
The safety profile of sunifiram is not well-established through comprehensive long-term toxicological studies. While acute toxicity appears low in animal models, the lack of rigorous clinical trials in humans means its side effect profile, potential for dependence, and long-term consequences are unknown. Anecdotal reports from unregulated use mention side effects such as headaches, irritability, and insomnia. Its status as an unapproved research chemical means it is not evaluated for safety or efficacy by major regulatory agencies, and its consumption carries inherent and undefined risks. It remains a compound of significant interest in nootropic research but is not recognized as a safe or approved therapeutic agent.
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