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Osthole

Name: Osthole
Brand: Cuicheng Bio
SKU: pr2606011590
Price: 20 USD
Availability: InStock

2 Inquiries

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CAS No.:

484-12-8

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Osthole (CAS Number: 484-12-8) is a natural coumarin derivative (chemically known as 7-methoxy-8-isopentenylcoumarin) extracted primarily from the fruits of Cnidium monnieri (She Chuang Zi). It functions as a highly versatile, multi-target pharmacological agent, a natural biopesticide, and a premium ingredient in dermatological and health formulations. [1, 2, 3, 4, 5]

Key Pharmacological Functions and Mechanisms

Anti-Osteoporotic and Bone-Building Support: Osthole is highly celebrated as a potent natural agent for bone health. It activates the Wnt/$\beta $-catenin signaling pathway and upregulates Bone Morphogenetic Protein-2 (BMP-2). This significantly accelerates osteoblast differentiation, proliferation, and bone mineralization while suppressing osteoclast-mediated bone resorption, making it a key molecule in postmenopausal osteoporosis research. [1, 2, 3, 4]
Anti-Inflammatory and Antipruritic (Anti-Itch) Effects: The compound acts as a powerful anti-inflammatory by inhibiting the NF-$\kappa\text{B}$ and MAPK cascades. This blocks the expression of inducible enzymes (iNOS and COX-2) and reduces pro-inflammatory cytokines like TNF-$\alpha $, IL-6, and IL-1$\beta $. In dermatological studies, it is widely used to relieve allergic dermatitis, eczema, and severe skin itching. [1, 2, 3, 4]
Antitumor Activity and Metastasis Inhibition: In cancer research, osthole exhibits selective cytotoxicity against various malignant cell lines, including lung, breast, prostate, and colorectal cancers. It suppresses PI3K/Akt/mTOR signaling, causing cell cycle arrest at the G2/M or G0/G1 phase and inducing mitochondrial apoptosis. It also downregulates matrix metalloproteinases (MMP-2 and MMP-9) to block tumor invasion and angiogenesis. [1, 2, 3, 4, 5]
Metabolic Regulation and Liver Protection: Osthole acts as a natural dual agonist for PPAR$\alpha $ and PPAR$\gamma $, while also activating the AMPK pathway. This enhances peripheral insulin sensitivity, slows down lipid synthesis, and accelerates fatty acid oxidation in the liver. It is highly effective in models targeting hyperlipidemia and Non-Alcoholic Fatty Liver Disease (NAFLD). [1, 2, 3]
Vasodilation and Cardiovascular Defense: It functions as a non-specific phosphodiesterase (PDE) inhibitor and calcium channel blocker. By preventing extracellular $\text{Ca}^{2+}$ influx, it relaxes vascular smooth muscles, leading to blood vessel dilation and blood pressure reduction. It also prevents abnormal platelet aggregation to guard against thrombosis. [1, 2, 3, 4]
Neuroprotection and Cognitive Enhancement: Osthole readily crosses the blood-brain barrier. It enhances the expression of Brain-Derived Neurotrophic Factor (BDNF) and mitigates microglial over-activation. In Alzheimer's models, it protects synaptic plasticity and alleviates the cognitive and memory deficits triggered by amyloid-beta (A$\beta $) accumulation. [1, 2, 3, 4, 5]

Agricultural and Analytical Functions

Eco-Friendly Botanical Biopesticide: In agricultural science, osthole is developed into a highly effective, green fungicide and insecticide. It shows potent contact and stomach poison mechanisms to control pests like aphids and cabbage caterpillars, and targets fungal pathogens responsible for powdery mildew, downy mildew, and fusarium wilt without causing environmental toxic runoff. [1, 2, 3, 4, 5]
Quality Control Reference Standard: Analytical laboratories rely on osthole as a definitive HPLC standard required by international pharmacopoeias to authenticate, evaluate, and standardize the chemical safety of Cnidium monnieri botanical extracts.

Basic Info

Product Name:

Osthol

Other Name:

2H-1-Benzopyran-2-one,7-methoxy-8-(3-methyl-2-buten-1-yl)-;Osthole;Coumarin,7-methoxy-8-(3-methyl-2-butenyl)-;2H-1-Benzopyran-2-one,7-methoxy-8-(3-methyl-2-butenyl)-;7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one;7-Methoxy-8-isopentenylcoumarin;Osthol;Ostole;Ostol;7-Methoxy-8-(3-methyl-2-butenyl)coumarin;8-(3-Methyl-2-butenyl)herniarin;NSC 31868;1440642-68-1

CAS No.:

484-12-8

Molecular Formula:

C15H16O3

InChIKeys:

InChIKey=MBRLOUHOWLUMFF-UHFFFAOYSA-N

Molecular Weight:

244.29

Exact Mass:

244.29

EC Number:

610-421-7

UNII:

XH1TI1759C

NSC Number:

31868

DSSTox ID:

DTXSID20197507

Color/Form:

Colorless needle like crystals|Prisms from ether|White powder

HScode:

2932209090

Categories:

Skin Conditioning

Characteristics

PSA:

35.5

XLogP3:

3.8

Appearance:

white

Density:

1.1±0.1 g/cm3

Melting Point:

83.5 °C

Boiling Point:

396.7°C at 760 mmHg

Flash Point:

167.6±22.5 °C

Refractive Index:

1.557

Water Solubility:

methanol: soluble 10mg/mL, clear, colorless

Storage Conditions:

room temp

Vapor Pressure:

6.9X10-6 mm Hg at 25 °C (est)

Henrys Law Constant:

Henry's Law constant = 1.46X10-6 atm-cu m/mol at 25 °C (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 1.26X10-1- cu cm/molec-sec at 25 °C (est)

See More Osthol Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Osthol Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Cosmetic raw materials Organic Intermediate	1000 KG	Jun 14, 2024
United States	Osthole	2 KG	Sep 29, 2024

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