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High-Purity N-Benzyloxycarbonyl-D-alanine N-Cbz-D-Alanine for Peptide Synthesis and Pharmaceutical Intermediates

Name: High-Purity N-Benzyloxycarbonyl-D-alanine N-Cbz-D-Alanine for Peptide Synthesis and Pharmaceutical Intermediates
Brand: ONERBIO
SKU: pr2606021270
Price: 10.45 USD
Availability: InStock

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CAS No.:

26607-51-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2026-10-07

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

5 days

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Details
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History Price

Description

Product Name: N-Benzyloxycarbonyl-D-alanine
Synonyms: N-Cbz-D-Alanine
CAS: 26607-51-2
MF: C11H13NO4
MW: 223.23
EINECS: 206-418-1
Appearance: White powder

N-Benzyloxycarbonyl-D-alanine is a purine nucleoside analog with potent antiviral and, to a lesser extent, antineoplastic (anti-cancer) activity. As a raw material (Active Pharmaceutical Ingredient, API), it is a white to off-white, odorless crystalline powder. Chemically, it is designated as 9-β-D-arabinofuranosyladenine (Ara-A). Its molecular formula is C₁₀H₁₃N₅O₄, and it possesses a molecular weight of 267.24 g/mol. The CAS registry number for Vidarabine is 5536-17-4. The raw material is typically supplied with a purity of ≥98% (often ≥99% by HPLC for high-grade pharmaceutical use).

As a raw material, the physical characteristics of Vidarabine are critical for formulation (e.g., ophthalmic ointments, intravenous injections, or research solutions).

Appearance: Fine, crystalline powder.
Solubility: Vidarabine is slightly soluble in water (approx. 1.5–2.0 mg/mL at 25°C) and very slightly soluble in ethanol and chloroform. It is more soluble in dilute acids and alkalis. This low aqueous solubility is a key parameter formulators must address when developing liquid dosage forms.
Melting Point: The substance decomposes upon melting, typically in the range of 257–260°C.
Stability: In the solid state, Vidarabine is relatively stable when stored in a dry, light-resistant container. However, in aqueous solution, it is susceptible to deamination (enzymatic or chemical conversion) to hypoxanthine arabinoside (Ara-Hx), which has significantly reduced antiviral activity. Therefore, solutions must be freshly prepared or stabilized.

Vidarabine acts primarily as a DNA polymerase inhibitor. Once taken up by virally infected cells, Vidarabine is phosphorylated intracellularly to the active triphosphate (Vidarabine triphosphate, Ara-ATP). The mechanism involves two key steps:

Selective Inhibition: Ara-ATP preferentially inhibits viral DNA polymerase (specifically Herpesviridae) compared to host cellular DNA polymerases. This selective toxicity is the basis of its antiviral action.
Chain Termination: Ara-ATP is incorporated into the growing viral DNA chain. Because it lacks the required 3'-hydroxyl group (present in deoxyadenosine), it acts as a non-reversible chain terminator, halting viral replication.

ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

As a raw material for finished pharmaceuticals, Vidarabine is historically recognized for its activity against:

DNA Viruses: Herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella-zoster virus (VZV), and Cytomegalovirus (CMV).
Clinical Use: Prior to the widespread use of Acyclovir, Vidarabine was a first-line therapy for severe Herpes simplex encephalitis and neonatal herpes. Today, its primary topical application is in the treatment of acute keratoconjunctivitis and recurrent epithelial keratitis caused by HSV. It is also used systemically (intravenous infusion) in some regions for immunocompromised patients with VZV infections.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

ECHEMI Editorial Reference

White to off-white solid

Research & Reference Note

High-Purity N-Benzyloxycarbonyl-D-alanine N-Cbz-D-Alanine for Peptide Synthesis and Pharmaceutical Intermediates is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

N-Cbz-D-Alanine

Other Name:

N-CARBOBENZOXY-D-ALANINE;N-CBZ-D-ALANINE;N-BENZYLOXYCARBONYL-D-ALANINE;N-ALPHA-CBZ-D-ALANINE;N-ALPHA-BENZYLOXYCARBONYL-D-ALANINE;N-ALPHA-CARBOBENZOXY-D-ALANINE;Z-D-ALANINE;Z-D-ALA-OH

CAS No.:

26607-51-2

Molecular Formula:

C11H13NO4

InChIKeys:

TYRGLVWXHJRKMT-MRVPVSSYSA-N

Molecular Weight:

223.23

Exact Mass:

223.084457

BRN:

2056163

EC Number:

206-418-1

HScode:

2924299090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

75.6

XLogP3:

1.4

Appearance:

White to off-white Crystalline Powder

Density:

1.2±0.1 g/cm3

Melting Point:

83-84°C

Boiling Point:

422.1°C at 760 mmHg

Flash Point:

209.1±26.8 °C

Refractive Index:

1.545

Storage Conditions:

2-8°C

Vapor Pressure:

0.0661mmHg at 25°C

See More N-Cbz-D-Alanine Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More N-Cbz-D-Alanine Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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High-Purity N-Benzyloxycarbonyl-D-alanine N-Cbz-D-Alanine for Peptide Synthesis and Pharmaceutical Intermediates

Product Details

Seller Information

History Price

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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