4-Chloro-2-nitroaniline | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 89-63-4

4-Chloro-2-nitroaniline Basic information
Product Name:
4-Chloro-2-nitroaniline
Synonyms:
fastred2ncsalt;redbase3gl;redbasecibavi;redbaseirgavi;redsaltcibavi;redsaltnbgl;Sanyo Fast Red Salt 3GL;sanyofastredsalt3gl
CAS:
89-63-4
MF:
C6H5ClN2O2
MW:
172.57
EINECS:
201-925-4
Product Categories:
Dyestuff Intermediates;Amines;Anilines, Aromatic Amines and Nitro Compounds;Organics;Aromatics;Mutagenesis Research Chemicals;Intermediates of Dyes and Pigments
Mol File:
89-63-4.mol

4-Chloro-2-nitroaniline Chemical Properties
Melting point 
117-119 °C(lit.)
Boiling point 
200°C (rough estimate)
density 
1.37
refractive index 
1.6460 (estimate)
Fp 
191 °C
storage temp. 
room temp
solubility 
0.5g/l (anhydrous substance)
pka
pK1: 1.10(+1) (25°C)
Colour Index 
37040
form 
Crystalline Powder or Chunks
color 
Orange
PH
7 (0.5g/l, H2O, 20℃)
Water Solubility 
INSOLUBLE
BRN 
512436
Henry's Law Constant
8.2×101 mol/(m3Pa) at 25℃, HSDB (2015)
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChI
1S/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
InChIKey
PBGKNXWGYQPUJK-UHFFFAOYSA-N
SMILES
Nc1ccc(Cl)cc1[N+]([O-])=O
CAS DataBase Reference
89-63-4(CAS DataBase Reference)
NIST Chemistry Reference
Aniline, 4-chloro-2-nitro-(89-63-4)
EPA Substance Registry System
4-Chloro-2-nitroaniline (89-63-4)
Safety Information
Hazard Codes 
T+,N,T
Risk Statements 
26/27/28-33-51/53
Safety Statements 
28-36/37-45-61-28A
RIDADR 
UN 2237 (CHLORONITROANILINES)
WGK Germany 
2
RTECS 
BX1575000
Autoignition Temperature
964 °F
Hazard Note 
Very Toxic
TSCA 
TSCA listed
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications
Acute Tox. 1 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1
Aquatic Chronic 2
STOT RE 2
Hazardous Substances Data
89-63-4(Hazardous Substances Data)

MSDS Information
Provider
Language
4-Chloro-2-nitroaniline
English
SigmaAldrich
English
ACROS
English
ALFA
English
4-Chloro-2-nitroaniline Usage And Synthesis
Chemical Properties
bright orange powder
Uses
A nitro-aromatic amine with mutagenicity and carcinogenicity
Uses
4-Chloro-2-nitroaniline is used almost exclusively as an intermediate in the synthesis of pigments. The greatest potential for human exposure to 4-chloro-2- nitroaniline is in production and use of pigments made from the compound.
Uses
4-Chloro-2-nitroaniline is used as pharmaceutical intermediate.
Production Methods
1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.
Preparation
4-Chloro-2-nitrobenzenamine of chlorine.
General Description
Bright orange powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents.
Hazard
Toxic by ingestion and inhalation.
Fire Hazard
4-Chloro-2-nitroaniline is probably combustible.
Purification Methods
Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]
4-Chloro-2-nitroaniline Preparation Products And Raw materials
Raw materials
2,5-Dichloronitrobenzene-->4-Chloro-2-nitroaniline
Preparation Products
Quizalofop-p-ethyl-->HANSA YELLOW 10G-->2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)-5-chlorobenzotriazole-->N-Acetyl-N-(4-chloro-2-nitrophenyl)acetamide-->5-[(4-chloro-2-nitrophenyl)azo]-1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile-->1,2,3,4-tetrahydro-Phenazine-->N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID-->8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione-->4-AMINO-3-NITROPHENYLBORONIC ACID, PINACOL ESTER-->5-CHLORO-2-IODOANILINE-->UV-320-->2,3,6-TRICHLOROQUINOXALINE-->DISPERSE YELLOW 211-->4-Chloro-2-nitroaniline