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Home > Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs > Efinaconazole for Sale > Efinaconazole High Purity 99% Antifungal API CAS 164650-44-6 NT
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Efinaconazole High Purity 99% Antifungal API CAS 164650-44-6 NT

3 Inquiries

Unit Price:

$110-140/G FOB

Get Latest Price
CAS No.:

164650-44-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

qingdao

Brand:

/

Packaging:

bag

Price valid (until):

2026-07-25

Company Type:
Trader
Location:
China
Qualification:
Main Products:

3-(1-Naphthoyl)indole

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Efinaconazole is a novel triazole antifungal drug, primarily indicated for the topical treatment of onychomycosis (fungal infection of the nail and toenails). It functions as a 14α-demethylase inhibitor, effectively inhibiting the biosynthesis of ergosterol, a critical component of fungal cell membranes.

    This high-purity API is suitable for pharmaceutical formulation development and manufacturing.


    Key Features:

    • High Purity: ≥ 99% (HPLC), meeting rigorous quality standards.

    • Mechanism: Potent inhibitor of fungal lanosterol 14α-demethylase (CYP51).

    • Efficacy: Highly active against key pathogens, including Trichophyton rubrum and Trichophyton mentagrophytes.

    • Applications: Used in topical solutions for the treatment of onychomycosis.


    Applications:

    • Pharmaceutical Industry: As an active pharmaceutical ingredient (API) in topical antifungal formulations (e.g., 10% solution).

    • R&D: For drug discovery and formulation development.

    Packaging: ___ (1kg, 5kg, or 25kg per package, as per customer's request)

    Storage: Store in a cool, dry, and well-ventilated area, away from direct sunlight and moisture. Keep container tightly closed. Recommended storage temperature: 2-8°C (Refrigerator) or below 25°C.

    Items Specifications
    Items Specifications
    Assay (by HPLC) 99.0% ~ 101.0%
    Appearance White to off-white crystalline powder
    Melting Point 86°C ~ 89°C
    Specific Rotation [α]₂₀/D -85° ~ -95° (c=1, Chloroform)
    Loss on Drying ≤ 0.5%
    Residue on Ignition ≤ 0.1%
    Heavy Metals (as Pb) ≤ 20 ppm
    Related Substances (Single Impurity) ≤ 0.5%
    Total Impurities ≤ 1.0%

    Basic Info
    Product Name:

    Efinaconazole

    Other Name:

    1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,(αR,βR)-;1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,[R-(R*,R*)]-;(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;KP 103 (pharmaceutical);KP 103;Efinaconazole;Jublia;(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(4H-1,3,4-triazol-4-yl)butan-2-ol

    CAS No.:

    164650-44-6

    Molecular Formula:

    C18H22F2N4O

    InChIKeys:

    InChIKey=NFEZZTICAUWDHU-RDTXWAMCSA-N

    Molecular Weight:

    348.3902864

    Exact Mass:

    348.39

    EC Number:

    1592732-453-0

    UNII:

    J82SB7FXWB

    DSSTox ID:

    DTXSID40167787

    NCI Thesaurus Code:

    C97998

    ATC Code:

    D - Dermatologicals

    Characteristics
    PSA:

    54.2

    XLogP3:

    2

    Density:

    1.26±0.1 g/cm3(Predicted)

    Boiling Point:

    512.2±60.0 °C(Predicted)

    Flash Point:

    263.6±32.9 °C

    Refractive Index:

    1.590

    Water Solubility:

    In water, 321.6 mg/L at 25 °C (est)

    Storage Conditions:

    Store at 20 °C to 25 °C (68 °F to 77 °F); excursions permitted to 15 °C to 30 °C (59 °F to 86 °F).|Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20 °C.

    Vapor Pressure:

    1.57X10-9 mm Hg at 25 °C (est)

    Henrys Law Constant:

    Henry's Law constant = 1.83X10-13 atm-cu m/mol at 25 °C (est)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.17X10-12 cu cm/molecule-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.2X10-17 cu cm/molecule-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Reproductive toxicity, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H361 Suspected of damaging fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    3-(1-Naphthoyl)indole

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    Bangladesh

    Efinaconazole

    12 KG May 16, 2025
    Hungary

    Efinaconazole

    5 PCS May 1, 2026
    United States

    Efinaconazole

    1 KG Jan 28, 2026
    Post an enquiry for this product
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