1. Product Overview
(S)-(+)-2-Amino-3-methylbutane, CAS 22526-46-1, is the (S)-enantiomer of 3-methyl-2-butylamine, a chiral primary aliphatic amine with molecular formula C₅H₁₃N and MW 87.16 g/mol. Also known as (S)-(+)-3-methyl-2-butylamine or ChiPros-grade chiral amine, it appears as a clear, colorless to pale yellow liquid at 20°C with a characteristic amine odor. It is optically active with specific rotation [α]/D +5.3° to +5.5° (neat). This compound is air-sensitive and highly flammable (flash point <21°C), miscible with water (~60 g/L at 20°C) and common organic solvents. It serves as a key chiral building block in asymmetric synthesis, pharmaceutical intermediate preparation, and diastereomeric salt resolution.
2. Key Features and Advantages
• High Enantiomeric Purity — ChiPros grade: ≥98% chemical purity with ee ≥97%, suitable for stereoselective synthesis.
• Defined Chirality — (S)-configuration with verified positive optical rotation (+5.3° neat), essential for enantiomer-specific bioactivity.
• Versatile Reactivity — Primary amine enables amidation, reductive amination, salt formation, and chiral ligand/scaffold construction.
• Broad Solubility — Miscible with water and soluble in alcohols, ethers, hydrocarbons; compatible with multi-phase systems.
• GMP-Sourced Option — Available from qualified suppliers for pharma R&D and custom synthesis pipelines.
3. Main Applications
(S)-(+)-2-Amino-3-methylbutane is used primarily in high-value chiral sectors: Pharmaceutical Intermediates (chiral amine scaffold for APIs requiring (S)-3-methylbutan-2-amine; precursor to chiral auxiliaries); Asymmetric Synthesis (diastereomeric salt formation, chiral resolution, ligand precursor for catalytic asymmetric transformations); Agrochemical R&D (enantiomerically pure pesticide/herbicide intermediates); Fine Chemical Research (standard for HPLC chiral column calibration and optical purity testing); Material Science (chiral modifier in supramolecular chemistry and MOF synthesis).
4. Technical Specifications
5. Storage and Handling
• Storage Conditions: Store in a cool, dry, well-ventilated area below 25°C, away from heat/open flames (flash point <21°C). Keep container tightly sealed under inert atmosphere (N₂ or Ar) to prevent oxidation and moisture uptake. Recommended: refrigerator (2–8°C) for long-term storage.
• Packaging Options: Research scale: 100 mg / 250 mg / 1 g / 5 g / 25 g amber vials with septum caps; bulk: 100 g / 500 g / 1 kg / 5 kg upon custom synthesis request.
• Shelf Life: Stable ≥12 months unopened under inert gas at 2–8°C; use open vial promptly.
• Handling Precautions: Use in fume hood with ventilation. Wear nitrile gloves, goggles, flame-resistant coat. Avoid vapor inhalation and skin/eye contact. Use spark-proof tools (Class 3 PG II flammable). Ground containers during transfer.
• Incompatible Materials: Strong oxidizers, acids, isocyanates, epoxy resins; keep from ignition sources.
6. Safety Overview
GHS pictograms: GHS02 (Flame), GHS05 (Corrosion), GHS06 (Skull), GHS07 (Exclamation), GHS09 (Environment). Signal word: Danger. Hazard statements: H225 (highly flammable liq/vapour), H302 (harmful if swallowed), H312 (skin contact harmful), H314 (severe skin/eye damage), H331 (toxic if inhaled), H411 (toxic to aquatic life long-lasting). Precautionary: P210/P261/P280/P305+P351+P338/P310/P403+P235. Transport: UN 2733, Class 3, PG II (corrosive flammable liquid). WGK Germany 3, RTECS UI1100000. For research use only; not for direct human/veterinary use. Dispose as hazardous flammable corrosive waste. In case of skin contact wash with water/soap; eyes rinse 15 min + medical aid; inhalation move to fresh air.
