—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • • • • • • • Product Overview

                                              4-Methyl-2-(tributylstannyl)pyridine is an organotin compound with the molecular formula C₁₈H₃₃NSn and a molecular weight of 382.17 g/mol. This colorless to pale yellow clear liquid is a valuable building block for Stille cross-coupling reactions, featuring a pyridine ring substituted with a tributylstannyl group at the 2-position and a methyl group at the 4-position. The stannyl group provides a versatile handle for palladium-catalyzed coupling with aryl, heteroaryl, and vinyl halides, enabling the construction of carbon-carbon bonds and the synthesis of complex molecular architectures.

                                              Synthetic Process

                                              4-Methyl-2-(tributylstannyl)pyridine is synthesized through the following routes:

                                              • Lithiation-stannylation: 4-Methyl-2-bromopyridine is treated with n-butyllithium to form the organolithium species, which is then reacted with tributyltin chloride to yield the stannyl pyridine.

                                              • Purification: The crude product is purified by distillation under reduced pressure.

                                              Mechanism of Action / Application Principles

                                              • Stille Coupling: The tributylstannyl group undergoes palladium-catalyzed cross-coupling with aryl, heteroaryl, or vinyl halides to form carbon-carbon bonds.

                                              • Pharmaceutical Synthesis: Used as a building block for the synthesis of pyridine-containing drug candidates.

                                              • Ligand Synthesis: The pyridine nitrogen can coordinate to metals, enabling the synthesis of functional ligands.

                                              Quality Specifications

                                              
                                              

                                              
                                              

                                              Parameter	Specification
                                              Assay	≥98.0%
                                              Appearance	Colorless to pale yellow clear liquid
                                              Density (20°C)	1.164 - 1.168 g/ml
                                              Refractive Index (n²⁰/D)	1.535 - 1.539
                                              Loss on Drying	≤0.5%

                                              Each batch is accompanied by a Certificate of Analysis (COA).

                                              Packaging & Storage

                                              • Research quantities: 100mg, 500mg amber glass vials

                                              • Bulk quantities: 1g, 5g amber glass vials

                                              Storage conditions: Store in a cool, dry place in tightly sealed containers, protected from light. Under recommended conditions, shelf life is 24 months.

                                              
                                              

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.