2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE

4-chloro-6-(trifluoromethyl)pyrimidin-2-amine (24)2-Amino-6-(trifluoromethyl)pyrimidin-4-ol (200 mg, 1.1 mmol) is dissolved in POCI33.4 g (0.186 mol) of 4-hydroxy-6-trifluoromethylpyrimidin-2-ylamine are added in portions (in each case ca. 5 g) to a mixture of 85 ml of phosphorus oxychloride and 47.5 ml of dimethylaniline and the mixture is heated at reflux until the added solid has dissolved. The mixture is then heated at reflux for a further 90 minutes. After cooling, the reaction mixture is added to ice water while observing the safety precautions for phosphorus oxychloride. The aqueous phase is extracted with methylene chloride, the organic phase is separated off and dried with sodium sulfate, and the drying agent is filtered off. Following concentration by evaporation, 47.8 g of a crude mixture are obtained. Following column chromatographic separation with ethyl acetate/heptane as eluent, 8.5 g of 4-chloro-6-trifluoromethylpyrimidin-2-ylamine were obtained (solid, 22percent yield, purity 95percent).2-amino-4-chloro-6-cyclopentylpyrimidine, m.p. 101.5-103 C. ... 2-amino-4-chloro-5-fluoro-6-methylpyrimidine; 2, 6-diamino-4-chloropyrimidine; 2-amino-4-chloro-6-trifluoromethylpyrimidine; and 2-amino-4-chloro-6-phenylpyrimidine.2-amino-4-chloro-6-cyclopentylpyrimidine, m.p. 101.5-103 C. ... 2-amino-6-benzyl-4-chloropyrimidine; 2-amino-4-chloro-6-cyclopropylpyrimidine; 2-amino-4-chloro-5-fluoro-6-methylpyrimidine; 2, 6-diamino-4-chloropyrimidine; 2-amino-4-chloro-6-trifluoromethylpyrimidine; and 2-amino-4-chloro-6-phenylpyrimidine.2-amino-4-chloro-6-cyclopentylpyrimidine, m.p. 101.5-103 C. ... 2-amino-4-chloro-5-fluoro-6-methylpyrimidine; 2, 6-diamino-4-chloropyrimidine; 2-amino-4-chloro-6-trifluoromethylpyrimidine; and 2-amino-4-chloro-6-phenylpyrimidine.Under an ice bath, add Example 15: 33.4 g (0.186 mol) of 4-hydroxy-6-trifluoromethylpyrimidin-2-ylamine are added in portions (in each case ca. 5 g) to a mixture of 85 ml of phosphorus oxychloride and 47.5 ml of dimethylaniline and the mixture is heated at reflux until the added solid has dissolved. The mixture is then heated at reflux for a further 90 minutes. After cooling, the reaction mixture is added to ice water while observing the safety precautions for phosphorus oxychloride. The aqueous phase is extracted with methylene chloride, the organic phase is separated off and dried with sodium sulfate, and the drying agent is filtered off. Following concentration by evaporation, 47.8 g of a crude mixture are obtained. Following column chromatographic separation with ethyl acetate/heptane as eluent, 8.5 g of 4-chloro-6-trifluoromethylpyrimidin-2-ylamine were obtained (solid, 22% yield, purity 95%).

Molecular Weight:197.54
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Exact Mass:196.9967593
Monoisotopic Mass:196.9967593
Topological Polar Surface Area:51.8
Heavy Atom Count:12
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes