4-Amino-1-methylpiperidine
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4-Amino-1-methylpiperidine
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CAS No:
41838-46-4
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Formula:
C6H14N2
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Chemical Name:
4-Amino-1-methylpiperidine
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Synonyms:
4-Piperidinamine,1-methyl-;Piperidine,4-amino-1-methyl-;1-Methyl-4-piperidinamine;4-Amino-1-methylpiperidine;1-Methyl-4-aminopiperidine;1-Methylpiperidin-4-ylamine;N-Methyl-4-aminopiperidine
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CAS No:
Characteristics
29.3
-0.1
colorless to light-yellow liquid
0.91
237-239 °C
83 °C @ Press: 48 Torr
39.2±13.6 °C
1.4700-1.4740
Safety Information
IRRITANT
2920
36/37/38-22-34-11
26-36/37/39-45-22-16-9
Xi,Xn
Irritant
P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
H226
|Danger|H226 (28.57%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 7 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Amino-1-methylpiperidine Use and Manufacturing
Step: 3A-1Synthesis of l-Methyl-piperidin-4-yIamineProcedure:Ammonium formate (2.226g, 0.035348mol) was added to a solution of 1 -Methyl- piperidin-4-one (lg, 0.008837mol) in MeOH and stirred for lOmins. 20percent Pd-C was added to this and the reaction mixture was heated at 60°C for 2hrs. The reaction was monitored by the TLC (10percent methanol in chloroform). The reaction mixture was filtered through celite bed, concentrated to afford lg (100percent yield) of l-Methyl-piperidin-4-ylamine.Ammonium formate (15.4 g; 240 mmol) and 10percent Pd/C (3.14 g; 29 mmol) are added to a solution of 1-methyl-4-piperidone (3.26 mL; 26.5 mmol) in aqueous methanol (80 mL, CHN-((4-methoxyphenyl)methyl)-4-amino-l-methylpiperidine (1 g, 4.27 mmol) was dissolved in 4percent formic acid in methanol (60 mL). 10percent Pd/C (1 g) was added under argon and the reaction mixture was heated to reflux for 24 h. The mixture was filtered through celite and the filtrate was acidified with cone. HCl to pH~l. a) a) Example 88
Computed Properties
Molecular Weight:114.19
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:114.115698455
Monoisotopic Mass:114.115698455
Topological Polar Surface Area:29.3
Heavy Atom Count:8
Complexity:64.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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