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Indoramin

Indoramin structure

CAS No:
26844-12-2
Formula:
C22H25N3O
Chemical Name:
Indoramin
Synonyms:
Benzamide,N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]-;Benzamide,N-[1-(2-indol-3-ylethyl)-4-piperidyl]-;N-[1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl]benzamide;Indoramin;3-[2-(4-Benzamidopiperidino)ethyl]indole;N-[1-(2-Indol-3-ylethyl)-4-piperidyl]benzamide;Wy 21901;Indoramine;33953-38-7
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Indoramin is a member of tryptamines.|Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action.|An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.

Indoramin Basic Attributes

Molecular Weight：

347.462

Exact Mass：

347.45

EC Number：

248-041-5

UNII：

0Z802HMY7H

DSSTox ID：

DTXSID7048370

ATC Code：

C - Cardiovascular system

HScode：

2933990090

Characteristics

PSA：

48.1

XLogP3：

3.93360

Density：

1.21g/cm3

Melting Point：

209 °C

Boiling Point：

600ºC at 760mmHg

Flash Point：

316.7ºC

Refractive Index：

1.657

Water Solubility：

51.7 [ug/mL]

Vapor Pressure：

2.36E-14mmHg at 25°C

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Indoramin

Indoramin Use and Manufacturing

Uses

Antihypertensive.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:347.5
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:347.199762429
Monoisotopic Mass:347.199762429
Topological Polar Surface Area:48.1
Heavy Atom Count:26
Complexity:454
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes