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LGK-974

LGK-974 structure

CAS No:
1243244-14-5
Formula:
C23H20N6O
Chemical Name:
LGK-974
Synonyms:
LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-9742',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide
Categories:
Biochemical Engineering > Inhibitors

Description

LGK974 is a potent and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM.

LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It derives from an acetamide.|WNT974 has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.

LGK-974 Basic Attributes

Molecular Weight：

396.4445

Exact Mass：

396.169861

UNII：

U27F40013Q

HScode：

2933990090

Characteristics

PSA：

93.6

XLogP3：

1.8

Density：

1.268±0.06 g/cm3(Predicted)

Boiling Point：

650.9±55.0 °C(Predicted)

Flash Point：

347.5±31.5 °C

Refractive Index：

1.652

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2-(2',3-Dimethyl-(2,4'-bipyridin)-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

Computed Properties

Molecular Weight:396.4
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:396.16985928
Monoisotopic Mass:396.16985928
Topological Polar Surface Area:93.6
Heavy Atom Count:30
Complexity:560
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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