5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE

5-iodo-3-trifluoromethyl-2-pyridinol C 80asolution of 2- hydroxy-3- (trifluoromethyl) pyridine C in a mixture of N-iodosuccinimide (NIS), acetonitrile and dimethyl formamide (DMF) was heated for2 hours at 80 , and 2- hydroxy-3 - trifluoromethyl-5- (iodo) pyridine I (yield of 80percentgreater) is formed.A solution of 2-hydroxy-3-(trifluoromethyl)pyridine C in a mixture of N-iodosuccinimide (NIS), acetonitrile, and dimethylformamide (DMF) is heated at 80° C. for 2 hours to produce 2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine I (greater than 80percent yield). The 2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine I is then mixed with POClStep A. 5-iodo-3-(trifluoromethyl)pyridin-2-ol A mixture of 3-(trifluoromethyl)pyridin-2-ol (3.0 g, 18.5 mmol) and N-iodosuccinimide (4.2 g, 18.5 mmol) in acetonitrile (25 mL) and DMF (25 mL) was heated at 80 °C for 2 hours. After the reaction mixture was cooled to room temperature, water was added and the resulting mixture was extracted with ethyl acetate (70 mL x 2). The extracts were combined, washed with brine (120 mL x 3), dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford 5-iodo-3-(trifluoromethyl)pyridin-2-ol as a yellow solid (4.0 g, 74percent). Step A. 5-iodo-3-(trifluoromethyl)pyridin-2-ol A mixture of 3-(trifluoromethyl)pyridin-2-ol (3.0 g, 18.5 mmol) and N-iodosuccinimide (4.2 g, 18.5 mmol) in CH(0614) A mixture of Compound 37C (0.537 g),

Molecular Weight:288.99
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:288.92115
Monoisotopic Mass:288.92115
Topological Polar Surface Area:29.1
Heavy Atom Count:12
Complexity:279
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes