2,4-DICHLORO-8-METHOXYQUINOLINE
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2,4-DICHLORO-8-METHOXYQUINOLINE
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CAS No:
32608-29-0
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Formula:
C10H7Cl2NO
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Chemical Name:
2,4-DICHLORO-8-METHOXYQUINOLINE
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Synonyms:
2,4-DICHLORO-8-METHOXYQUINOLINE;Quinoline,2,4-dichloro-8-methoxy-;SCHEMBL1564603;CTK4G9005;KS-00000KIQ;DTXSID80651211;ZINC19721901;AKOS016013150;DS-5068;AK126154
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2,4-DICHLORO-8-METHOXYQUINOLINE Use and Manufacturing
General synthesis route of the compound was described schematicallyin Scheme 1. 2, 4-Dichloro-8-methoxy quinoline, wassynthesized according to literature report [27, 28], equimolarmixture of o-anisidine and malonic acid were refluxed with 30 mlof phosphorous oxy chloride on a heating mantle maintained at atemperature of 80e100 C for 5 h. On completion of the reaction(monitored by TLC), the reaction mixture was cooled and pouredslowly onto the crushed ice with continuous stirring. The solidseparated was filtered, dried and washed thoroughly with water.Column purification (95:5 hexaneeEtOAc) of the crude solid gave4-dichloro-8-methoxy quinoline, in a good yield (78.6percent).