Fradafiban
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Fradafiban
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CAS No:
148396-36-5
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Formula:
C20H21N3O4
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Chemical Name:
Fradafiban
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Synonyms:
3-Pyrrolidineacetic acid,5-[[[4′-(aminoiminomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-,(3S,5S)-;3-Pyrrolidineacetic acid,5-[[[4′-(aminoiminomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-,(3S-trans)-;(3S,5S)-5-[[[4′-(Aminoiminomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-3-pyrrolidineacetic acid;Fradafiban;BIBU 52;158516-54-2
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CAS No:
Description
Fradafiban is a pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl group (the S,S-diastereoisomer). A figrinogen receptor antagonist. It has a role as a platelet glycoprotein-IIb/IIIa receptor antagonist. It is a monocarboxylic acid, a carboxamidine and a member of pyrrolidin-2-ones.
Drug Information
Investigated for use/treatment in angina.
Fradafiban is a glycoprotein IIb/IIIa receptor antagonist. Activation of the platelet glycoprotein (GP IIb/IIIa) receptor on the platelet surface is the final pathway of platelet aggregation that may lead to embolism, which is one on the cause of angina.
5-((((4'-aminoiminomethyl)-(1,1'-biphenyl)-4-yl)oxy)methyl)-2-oxo-3-pyrrolidineacetic acid
Computed Properties
Molecular Weight:367.4
XLogP3:1.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:367.15320616
Monoisotopic Mass:367.15320616
Topological Polar Surface Area:126
Heavy Atom Count:27
Complexity:551
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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