2-Methylquinoline
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2-Methylquinoline
structure -
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CAS No:
91-63-4
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Formula:
C10H9N
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Chemical Name:
2-Methylquinoline
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Synonyms:
Quinoline,2-methyl-;Quinaldine;2-Methylquinoline;Khinaldin;NSC 3397;2-Methylchinoline
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CAS No:
Description
yellowish-brown liquid
Quinaldine appears as a colorless oily liquid darkening to red-brown on exposure to air. Flash point 175°F. Denser than water and slightly soluble in water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make dyes, pharmaceuticals and other chemicals.|Liquid
Quinaldine appears as a colorless oily liquid darkening to red-brown on exposure to air. Flash point 175°F. Denser than water and slightly soluble in water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make dyes, pharmaceuticals and other chemicals.|Quinaldine is a quinoline compound in which the quinoline skeleton is substituted at C-2 with a methyl group.
2-Methylquinoline Basic Attributes
143.19
143.19
110309
202-085-1
DVG30M0M87
3397
DTXSID3040271|DTXSID00872926
29334990
Characteristics
12.9
2.59
White to slightly yellow Crystalline Powder
1.038 g/cm3 @ Temp: 20 °C
-1.5 °C
246.5 °C
175 °F
1.625
Practically insoluble in water;chloroform: soluble (lit.)
Store below +30°C.
<0.1 hPa (20 °C)
Oral-rat LD50: 1230 mg/kg
Thermal decomposition of toxic nitrogen oxide gas
Slightly soluble in water.
Amines, Phosphines, and Pyridines
QUINALDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Keep tightly closed and protected from light (NTP, 1992).
Safety Information
6.1
NA 1993 / PGIII
3
21/22-68-36/37/38
36-45-36/37/39-26
UZ9625000
Xn
The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials
Stable, but may be light sensitive. Combustible. Incompatible with strong oxidizing agents.
P280
H302 + H312
This compound is probably combustible. (NTP, 1992)
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P312, P322, P330, P337+P313, P363, and P501|Aggregated GHS information provided by 375 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]
Drug Information
SYMPTOMS: Acute exposure to this compound will result in irritation to skin and mucous membranes. ACUTE/CHRONIC HAZARDS: This compound is a strong irritant to the mucous membranes. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
2-methylquinoline
2-Methylquinoline Use and Manufacturing
It can be extracted from coal tar or prepared by synthetic method. The naphthalene oil fraction and the oil-washed fraction are washed with sulfuric acid to obtain a quinoline sulfate base solution. Steam is used to remove impurities such as neutral oil, and then decomposed with alkali or ammonia. The separated crude quinoline and base homologues are dehydrated Afterwards, it is rectified with a high-efficiency distillation column of 60 theoretical trays, and the distillation section with a boiling range of 237.5-239.5°C in the base is cut to obtain the crude quinoline; continue to cut the distillation section with a boiling range of 243-246°C as Extract the raw materials of isoquinoline and 2-methylquinoline; continue to cut the distillate section of 260-267°C as the raw material for the extraction of 4-methylquinoline. The fraction at 243-246°C was separated into 2-methylquinoline in the form of hydrochloride. The crystal of 2-methylquinoline hydrochloride was washed with benzene, and then the salt was decomposed with 20% sodium hydroxide solution. -247.4 ℃ fractions can obtain 2-methylquinoline with purity greater than 95%. 2-Methylquinoline can be synthesized by the reaction of aniline and 2, 3-dibromobutyraldehyde.
A useful ingredient in anti-malaria drugs, in manufacturing dyes, food colorants , pharmaceuticals and pH indicators.
Corrosion inhibitors and anti-scaling agents
Oil and gas drilling, extraction, and support activities|Quinoline, 2-methyl-: ACTIVE
Computed Properties
Molecular Weight:143.18
XLogP3:2.6
Hydrogen Bond Acceptor Count:1
Exact Mass:143.073499291
Monoisotopic Mass:143.073499291
Topological Polar Surface Area:12.9
Heavy Atom Count:11
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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