8-Hydroxy-2-methyl-4(3H)-quinazolinone
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8-Hydroxy-2-methyl-4(3H)-quinazolinone
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CAS No:
90417-38-2
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Formula:
C9H8N2O2
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Chemical Name:
8-Hydroxy-2-methyl-4(3H)-quinazolinone
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Synonyms:
4(3H)-Quinazolinone,8-hydroxy-2-methyl-;4(1H)-Quinazolinone,8-hydroxy-2-methyl-;8-Hydroxy-2-methyl-4(3H)-quinazolinone;Nu 1025;NSC 696807
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CAS No:
Description
NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity[1][2][3].
Characteristics
61.7
0.35
off-white solid
1.4±0.1 g/cm3
248 °C
345.4±44.0 °C at 760 mmHg
162.7±28.4 °C
1.678
DMSO: 35 mg/mL, soluble
−20°C
8-Hydroxy-2-methyl-4(3H)-quinazolinone Use and Manufacturing
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
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8-Hydroxy-2-methyl-4(3H)-quinazolinone
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