This product can inhibit the synthesis of prostaglandins and has antipyretic and analgesic effects

This product belongs to the macrolide antibiotics. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), all groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, certain spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on certain bacteria at high concentrations. It can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" site), blocking the transfer RNA (t-RNA) from binding to the "P" site, and also blocking the self-acceptor site ("A" site) of the polypeptide chain.

It participates in amino acid metabolism, synthesis of neurotransmitters, synthesis of collagen and tissue cell interstitial, can reduce the permeability of capillaries, accelerate blood coagulation, stimulate coagulation function, promote iron absorption in the intestine, promote the decrease of blood lipids, increase resistance to infection, participate in detoxification function, and has antihistamine effect and prevents the formation of carcinogens (nitrosamines).

This product is a dopamine 2 (D2) receptor antagonist, and also has a 5-hydroxytryptamine 4 (5-HT4) receptor agonist effect, and has a mild inhibitory effect on 5-HT3 receptors. It can act on dopamine receptors in the medullary chemo-emetic zone (CTZ) to increase the threshold of CTZ, and has a strong central antiemetic effect. This product can also block hypothalamic dopamine receptors, inhibit prolactin inhibitory factor, and promote the secretion of prolactin, so it has a certain lactation effect. The inhibitory effect on other parts of the central nervous system is relatively small, with a weak sedative effect and less hypnotic effect. The main effect on the gastrointestinal tract is on the upper digestive tract, promoting the movement of the stomach and upper intestinal segments; increasing the tension of the gastrointestinal sphincter in the resting state, increasing the tension and contraction amplitude of the lower esophageal sphincter, increasing the pressure at the lower end of the esophagus, blocking gastroesophageal reflux, strengthening gastric and esophageal peristalsis, and enhancing the ability to clear the contents of the esophagus, promoting gastric emptying; promoting the relaxation of the pylorus, duodenum and upper jejunum, forming functional coordination between the gastric antrum, gastric body and upper small intestine. These effects can also enhance the antiemetic effect of this product. The transmission effect of this product on the small intestine and colon is still uncertain.

This product is a tricyclic antidepressant. Its function is to inhibit the reuptake of 5-hydroxytryptamine and norepinephrine by the central nervous system, thereby increasing the concentration of these two neurotransmitters in the synaptic cleft and exerting an antidepressant effect. It also has antianxiety and sedative effects.