This product is a semi-synthetic aminoglycoside antibiotic with strong antibacterial activity against aerobic Gram-negative bacilli, good antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, etc., and also good antibacterial effects against Mycobacterium tuberculosis, atypical mycobacteria and Staphylococcus aureus. This product is stable to aminoglycoside acetyltransferase AAC (3), and strains that can produce this enzyme and are resistant to kanamycin, gentamicin, tobramycin and sisomicin are sensitive to this product. This product can often achieve synergistic effects when used in combination with beta-lactams. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. Animal test data show that this product has lower ototoxicity than gentamicin and tobramycin, and lower nephrotoxicity than gentamicin.

This product is a selective 5-HT3 receptor antagonist. Its mechanism of action may be to antagonize the 5-HT3 receptors in the peripheral vagus nerve endings and central chemoreceptor areas, thereby blocking the vomiting reflex caused by factors such as chemotherapy and surgery that promote the release of 5-HT from intestinal chromaffin cells and excite the vagus afferent nerves. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.

This product is a chemically semi-synthetic clindamycin derivative. After entering the body, it is rapidly hydrolyzed into clindamycin to show its pharmacological activity. The antibacterial spectrum, antibacterial activity and therapeutic effect are the same as those of clindamycin, but its fat solubility and permeability are better than those of clindamycin, and it can be administered by intramuscular injection and intravenous drip. Compared with lincomycin, this product has a 4-8 times stronger antibacterial effect, good absorption, high bone concentration, and good efficacy against anaerobic infections. It has strong antibacterial activity mainly against Gram-positive cocci and anaerobic bacteria.