Thiamphenicol
15318-45-3
Food Grade
QINGDAO
25kg/10kg Drum
2016-08-31
Thiamphenicol,3-Phenyl-L-alanine benzyl ester 4-toluenesulphonate,7-Chloro-2-methylquinoline,N-Boc-L-pyroglutamic acid,L(-)-Carnitine,Florfenicol
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Product Description
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Seller Information
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Description
English name: THIAMPHENICOL
Molecular formula: C12H15CI2NO5S
Sex form: white to white crystalline powder or crystals
Point: thiamphenicol - chloramphenicol for broad spectrum antibiotics, its chemical structure similar to chloramphenicol, its thiamphenicol base instead of chloramphenicol nitrocellulose, and thus reduce its toxicity in vivo antibacterial activity 2.5 5 times more than chloride toxins. Against gram-positive bacteria such as lung, hemolytic streptococcus antibacterial effect is very strong, such as neisseria gonorrhoeae of gram positive bacteria, meningitis diplococcus, pulmonary bacteroides, escherichia coli and vibrio cholera, dysentery bacillus and influenza bacillus had stronger antibacterial effect, the anaerobic bacteria, rickettsia, amoeba, etc also have certain antibacterial function, its mechanism of action is the same as the chloramphenicol. Mainly inhibit a and protein synthesis, the drug oral absorption, blood levels within 2 hours can reach the highest peak, has a half-life of 5 hours, than the chloramphenicol lasting, bacteria have complete cross resistance between this product and chloramphenicol, stabler and tetracycline medicine has some cross resistance phenomenon. Clinically, thiamphenicol toxin is mainly used in respiratory, urinary, liver and gallbladder, typhoid intestinal surgery, obstetrics and gynecology and ent disease such as infection, especially for mild infection effect is particularly obvious. Thiamphenicol also have stronger immune inhibition, it is a good immune inhibitors. Its mechanism has significantly different with other immunosuppressants, chloramphenicol high several times the immunosuppressive effect. To reflect the extension of transplant surgery and homogeneous allograft transplantation effective agent
Basic Info-
Product Name:
Thiamphenicol
Other Name:Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-;Acetamide,2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]-,D-threo-(+)-;Acetamide,2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-,[R-(R*,R*)]-;2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide;(Methylsulfonyl)chloramphenicol;8065CB;Win 5063-2;Dextrosulphenidol;D-d-threo-2-Dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol;Thiamphenicol;D-Thiocymetin;D-Thiophenicol;Thiocymetin;Thiophenicol;D-threo-(1R,2R)-1-(p-Methylsulfonylphenyl)-2-dichloroacetamido-1,3-propanediol;(+)-Thiamphenicol;NSC 522822;Tirsan;(2′R,3′R)-Thiamphenicol;90-91-5;3785-14-6;14786-51-7;32430-04-9
CAS No.:15318-45-3
Molecular Formula:C12H15Cl2NO5S
InChIKeys:InChIKey=OTVAEFIXJLOWRX-NXEZZACHSA-N
Molecular Weight:356.22200
Exact Mass:356.22
EC Number:239-355-3
UNII:FLQ7571NPM
NSC Number:758396
DSSTox ID:DTXSID5021338
ATC Code:J01BA02|J - Antiinfectives for systemic use
HScode:2941400000
Categories:
Characteristics-
PSA:
112.08000
XLogP3:-0.3
Appearance:off-white solid
Density:1.55 g/cm3
Melting Point:165.3 °C
Boiling Point:695.9ºC at 760mmHg
Flash Point:374.7ºC
Refractive Index:1.589
Water Solubility:ethanol: 50 mg/mL, clear, colorless
Collision Cross Section:170.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|179.09 Ų [M-H]-
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Thiamphenicol,3-Phenyl-L-alanine benzyl ester 4-toluenesulphonate,7-Chloro-2-methylquinoline,N-Boc-L-pyroglutamic acid,L(-)-Carnitine,Florfenicol
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Location:
Taizhou Huangyan Jiangkou Chemical District Road
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Payment Terms:
D/P
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Average lead Time:
60
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Total Annual Revenue:
Less than $1 million
Runkang Pharmaceutical is an integrated enterprise specialized in drug preparation, API, veterinary API and intermediate, and also the largest API production base of Thiamphenicol in the world. 90% of products have been exported to Europe, America and Southeast Asia.
Science & Technology innovation is the inexhaustible resource of enterprise. The company has cooperated with Shanghai Institute of Materia Medica, Shanghai Research Institute of Chemical Industry, Zhejiang University of Technology, Shenyang Research Institute of Chemical Industry and other scientific research units in the development of new products, the core competitiveness has been strengthened. The company produces about 1 billion tablets of troche & capsule, and about a thousand tons of each kind of API every year. At present, about 38 products of the company have got GMP certificate.The main products of Zhejiang Runkang Pharmaceutical Co., Ltd. contain: thiamphenicol, florfenicol, ciprofloxacin HCL and some other veterinary API. -
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