Factory Supply Top Purity Benfotiamine CAS22457-89-2
GMP HALAL KOSHER ISO FDA 3 Inquiries
22457-89-2
Pharmaceutical Grade
0%
Boil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Inquiry History
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Description
Name Benfotiamine CAS 22457-89-2 EINECS 245-013-4 MF C19H23N4O6PS Grade Standard Medicine Grade Purity 98.0%~102.0% Type Antibiotic and Antimicrobial Agents MW 466.45 Certificate ISO Shelf life 2 Years
Benfotiamine is vitamin B1 fat soluble derivative, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve
the blood and tissue concentrations of thiamine, so as to improve the curative effectBenfotiamine is primarily marketed as an antioxidant dietary supplement. In a clinical study with six patients, benfotiamine lowered AGE by 40%.
Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to
benfotiamine are extrapolated from in vitro and animal studies. Unfortunately, apparent evidence from human studies is scarce and
especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of
benfotiamine in both diabetic and non-diabetic pathological conditions".It is thought that treatment with benfotiamine leads to increased intracellular thiamine diphosphate levels, a cofactor of transketolase.
This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway,
thus reducing tissue AGEs.
COA of BenfotiamineTest Item
Analysis Specification
Result
Description
White to almost white crystal
White to almost white crystal
Identification
A: IR spectra shows the similarity between sample and standard
B: The retention time of the major peak corresponds with it of the reference standard
Complies
Complies
Solution color and clearness
Colorless to a pale yellow clear solution
Complies
Chlorides
Not more than 0.053%
<0.053%
Sulphate
Not more than 0.011%
<0.011%
Loss on drying
Not more than 1.5%
0.66%
Heavy metals
Not more than 0.002%
<0.002%
Related Substances
TMP :Not more than 0.15%
Benzoic acid: not more than0.1%
Amide: not more than 0.40%
Single unknown impurity: not more than0.1%
Thiamine: not more than0.1%
Total impurities: Not more than 1.5%
<0.025%
No detectable
0.06%
0.08%
No detectable
0.33%
Residual solvents
Dichloromethane: not more than 600ppm
Isopropanol: not more than300ppm
No detectable
64ppm
Microbial limits
Total bacteria: not more than100cfu/g
Yeast and mold: not more than50cfu/g
Escherichia coli: no detectable
<10 cfu/g
<10 cfu/g
No detectable
Assay(Dry Basis)
98.0%~102.0%
99.6%
Conclusion
Complies with company Standard.
1. Benfotiamine powder is used for the prevention and treatment of vitamin B1 deficiency;
2. For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during
strenuous manual labor, etc.);
3. Benfotiamine is used in the treatment of nonalcoholic wernicke encephalopathy;
4. To treat beriberi;
5. Used in the following diseases, speculation, and vitamin B1 deficiency and metabolic disorders associated with treatment, such as:
neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other
gastrointestinal motor function obstacle.
CertificatesBasic Info-
Product Name:
Benfotiamine
Other Name:Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester;Benzoic acid,thio-,S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester);Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester;Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-,S-benzoate O-(dihydrogen phosphate);N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate;Benfotiamine;Benzoylthiamine monophosphate;Benzoylthiamine O-monophosphate;S-Benzoylthiamine monophosphate;S-Benzoylthiamine O-monophosphate;Biotamin;BTMP;Nitanevril;Neurostop;Vitanevril;Berdi;Betivina;Bietamine;Tabiomyl;Benfothiamine;8088CB;Milgamma;137-74-6
CAS No.:22457-89-2
Molecular Formula:C19H23N4O6PS
InChIKeys:InChIKey=BTNNPSLJPBRMLZ-UHFFFAOYSA-N
Molecular Weight:466.45
Exact Mass:466.45
EC Number:245-013-4
UNII:Y92OUS2H9B
DSSTox ID:DTXSID3045433
ATC Code:A - Alimentary tract and metabolism
Categories:
Characteristics-
PSA:
181
XLogP3:3.84720
Appearance:shinning black powder
Density:1.4±0.1 g/cm3
Melting Point:165 °C (decomp)
Boiling Point:745.1°C at 760 mmHg
Flash Point:404.4±35.7 °C
Refractive Index:1.645
Storage Conditions:2-8°C
Vapor Pressure:2.55E-23mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
India
Benfotiamine 98% white powder 22457-89-2 Senwayer
5 MT Sep 28, 2023 
Brazil
BENFOTIAMINA
20.00 KG Jun 28, 2023 
Mexico
Benfotiamine
1 KG Jun 18, 2025 Post an enquiry for this product