Product
Supplier
Encyclopedia
Inquiry
Lovastatin 99% buy - large image1
Lovastatin 99% buy - image1

Lovastatin 99%

3 Inquiries

Unit Price: Get Latest Price
CAS No.:

75330-75-5

Content:

99%

Port:

Shanghai

Packaging:

25kg

Price valid (until):

2022-07-31

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Calcium polystyrene sulfonate,Megestrol Acetate,Eperisone Hydrochloride

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


     Lovastatin is a hexahydronaphthalene ester isolated from Aspergillus terrestris culture medium. It is an inactive lactone. It has activity only after being hydrolyzed after oral administration. It has a strong competitive inhibitory effect on HMG CoA reductase in the liver. HMG CoA reductase is the rate limiting enzyme for de novo cholesterol synthesis in vivo. Inhibition of the enzyme can block the conversion of HMG CoA to methylvaleric acid, significantly reduce cholesterol synthesis, increase the expression of LDL receptor in liver and enhance the clearance of plasma LDL-C. Reduced cholesterol synthesis can also reduce apoB100 synthesis in the liver, thus reducing VLDL synthesis. Clinical observation shows that this product has a good effect on lowering plasma total cholesterol and LDLC in hypercholesterolemia caused by heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, diabetes or nephrotic syndrome. Statins are secondary metabolites of filamentous fungi, which can selectively inhibit the activity of hydroxymethylglutaric acid coenzyme A (HMG CoA) reductase and block the synthesis of cholesterol chemical book, which is related to the similarity of the acid structure of statins and HMG CoA. At present, such drugs (statins) used in humans mainly include natural statins and synthetic statins.

    Basic Info
    Product Name:

    Lovastatin

    Other Name:

    SiMvastatin EP IMpurity E;Lovastatin,Monacolin K;8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-nap;6alpha-Methylcompactin Mevinolin Monacolin K;)ethyl]-1-naphthalenylester;[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci

    CAS No.:

    75330-75-5

    Molecular Formula:

    C24H36O5

    InChIKeys:

    PCZOHLXUXFIOCF-BXMDZJJMSA-N

    Molecular Weight:

    404.54

    Exact Mass:

    404.54

    EC Number:

    616-212-7

    Color/Form:

    White

    HScode:

    29322090

    Characteristics
    PSA:

    72.8

    Physical Properties:

    Appearance: White, nonhygroscopic crystalline powder. Solubility: Insoluble in water (0.0004mg/mL); sparingly soluble in ethanol, methanol, isobutanol, isopropanol, acetonitrile, n-propanol; soluble in acetone, N-dimethylformamide; freely soluble in chloroform. Melting point: 174.5°C. Specific optical rotation: 25°C for D (sodium) line, +323° (concentration 0.5 g in 100 ml acetonitrile). Stability: Lovastatin is sensitive to light. Following exposure to extreme light conditions, the drug is stable for 24h or 1month when exposed to UV (approximately 3230 lux) or fluorescent (approximately 10,764 lux) light, respectively, at 28°C in air.

    XLogP3:

    4.08

    Appearance:

    Solid

    Density:

    1.12±0.1 g/cm3(Predicted)

    Melting Point:

    175°C

    Boiling Point:

    559.2±50.0 °C(Predicted)

    Flash Point:

    185.3±23.6 °C

    Refractive Index:

    320 ° (C=0.5, CH3CN)

    Water Solubility:

    0.0004 mg/mL at 25 ºC

    Storage Conditions:

    2-8°C

    Vapor Pressure:

    0Pa at 25℃

    Toxicity:

    LD50 orally in mice: >1000 mg/kg (Endo)

    Specific rotation:

    D25 +323° (c = 0.5 g in 100 ml acetonitrile)

    PKA:

    13.49±0.40(Predicted)

    Critical Temperature & Pressure:

    -20°C

    Hazard Identification

    Classification of the substance or mixture

    Skin sensitization, Category 1

    Carcinogenicity, Category 2

    Reproductive toxicity, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H317 May cause an allergic skin reaction

    H351 Suspected of causing cancer

    H361 Suspected of damaging fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P203 Obtain, read and follow all safety instructions before use.

    Response

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Calcium polystyrene sulfonate,Megestrol Acetate,Eperisone Hydrochloride

    Location:

    room610,xueshi road

    Payment Terms:

    TT against copy of documents

    Average lead Time:

    15

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2020

    zhengjiang langbo pharma is a leading Manufactory supplier of Acetic acid, Benzyl alcohol, PE based in Ningbo, Zhejiang, China. With a commitment to quality and customer satisfaction, zhengjiang langbo pharma has become a trusted name in the industry. Our product line includes a range of high-quality Acetic acid, Benzyl alcohol, PE, which are available at competitive prices. zhengjiang langbo pharma has established itself as a reliable supplier of chemical products on the echemi.com.

  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Lovastatin

    1 KG Jun 28, 2024
    United States

    Red yeast rice

    1 KG Apr 21, 2026
    India

    Red Yeast Rice Extract

    1.00 MT Jun 29, 2026
    Post an enquiry for this product
pic ×

Scan the QR Code to Share

All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.

According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

The information shown above is provided by the enterprise itself, and the authenticity, accuracy and legitimacy of the content are the responsibility of the publishing company. ECHEMI does not bear any guarantee responsibility for this. Please be aware that risks in internet transactions objectively exist.

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.