High Purity Peptide Irgd Tfa/Irgd Peptide CAS 1392278-76-0
What is Irgd Tfa/Irgd Peptide?
iRGD is a 9-amino acid cyclic peptide and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice.The peptide was able to home to tumor tissues, but in contrast to standard RGD (Arginylglycylaspartic acid) peptides, also spread much more extensively into extravascular tumor tissue. It was later identified that this extravasation and transport through extravascular tumor tissue was due to the bifunctional action of the molecule: after the initial RGD-mediated tumor homing, another pharmacological motif is able to manipulate tumor microenvironment, making it temporarily accessible to circulating drugs. This second step is mediated through specific secondary binding to neuropilin-1 receptor, and subsequent activation of a trans-tissue pathway, dubbed the C-end Rule, or CendR pathway.
| Items | Specifications |
| Product name | Irgd Tfa/Irgd Peptide? |
| CAS No. | 1392278-76-0 |
| MF | C35H57N13O14S2 |
| MW | 948.04 |
| EINECS No. | / |
| Sequence | H-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide bridge: Cys1-Cys9) |
| Density | 1.68±0.1 g/cm3(Predicted) |
| Appearance | white powder |
| Shelf Life | 2 Years When Properly Stored |
| Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
Application & Function
iRGD peptide-mediated tumor penetration occurs in three steps:binding to αv-integrins on tumor vasculature or tumor cells,exposure by proteolysis of a C-terminal motif that binds tneuropilin-1(NRP-1) and cel linternalization.iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells,which express NRP-1 and integrins.iRGD insertion does not impair virus infection and replication.iRGD peptide alone has no obvious effect on gastric cancer cells,and when combined with 5-FU,iRGD peptide (0.3μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1.
Company Information
Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.
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FAQ
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