API Furazolidone

Name	Furazolidone
CAS number	67-45-8
Synonym	Furazolidone; Furazolidine; Furoxone; Nitrofurazolidone; Nitrofuroxon; Furazolidon
Description	Furazolidone is a nitrofuran antibacterial agent. It is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.
Structure
Molecular Formula	C8H7N3O5
Molecular Weight	225.160
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Furazolidone More Info

1. Chemical and Classification

Furazolidone is a nitrofurantoin - type antibacterial agent. Its chemical name is 3 - (5 - nitro - 2 - furfurylideneamino)-2 - oxazolidinone. It belongs to the class of nitrofurans. Nitrofurans are a group of antibiotics that have antibacterial activity against both Gram - negative and Gram - positive bacteria.

2. Pharmacological Mechanism

Antibacterial Action: Furazolidone exerts its antibacterial effect by interfering with the bacterial enzyme systems involved in carbohydrate metabolism. Specifically, it inhibits enzymes such as acetyl - CoA in bacteria, thereby affecting the energy - metabolism process of bacteria, and achieving bactericidal or bacteriostatic effects.

Antibacterial Spectrum: It has a broad - spectrum antibacterial effect. It shows significant antibacterial activity against enteric bacteria such as Salmonella, Shigella, and Escherichia coli. For example, in the treatment of intestinal infections caused by Salmonella, furazolidone can effectively inhibit the growth and reproduction of Salmonella and alleviate symptoms such as diarrhea and abdominal pain.

3. Therapeutic Applications

Indications: It is mainly used for the treatment of infectious diarrhea, such as bacillary dysentery and enteritis caused by sensitive bacteria. In the treatment of bacillary dysentery, furazolidone can act against Shigella to reduce intestinal inflammatory responses and shorten the disease course.

Dosage and Administration: The dosage of furazolidone varies depending on the patient's age, weight, and specific condition. For adults, the usual oral dose is 0.1 g three times a day. For children, the dose should be adjusted according to their body weight under the guidance of a doctor.

4. Adverse Reactions and Precautions

Adverse Reactions: Common adverse reactions include nausea, vomiting, and abdominal discomfort. Some patients may have allergic reactions, such as rash and itching. It may also cause neurological symptoms such as dizziness and headache.

Precautions: It is important to use this drug under the guidance of a doctor. Especially for patients with a history of gastrointestinal diseases or an allergic constitution, it needs to be used with caution. At the same time, alcohol should be avoided during the medication period, because alcohol may interact with furazolidone and increase the risk of adverse reactions.