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Mechanism of Action

1.Inhibits the folate cycle and de novo purine biosynthesis, leading to increased intracellular levels of AICAR, a natural activator of AMP-activated protein kinase (AMPK). This results in energy-independent activation of AMPK, a master regulator of cellular metabolism.

2.Under conditions of metabolic stress, MOTS-c can translocate from the mitochondria to the nucleus, where it regulates the expression of nuclear genes. This establishes a unique mitochondria-to-nucleus signaling pathway, distinguishing it from most peptides encoded by nuclear DNA.

3.Upregulates GLUT4 (glucose transporter type 4) expression in skeletal muscle, enhancing glucose uptake by muscle cells and promoting fatty acid oxidation and lipid utilization.

Biological Functions

MOTS-c is an important mitochondrial-derived signaling peptide that has attracted significant scientific interest due to its role in metabolic regulation. Its reported biological activities include:

1.Activation of the AMP-activated protein kinase (AMPK) pathway

2.Enhancement of glucose uptake and utilization

3.Regulation of metabolic homeostasis

4.Reduction of obesity and insulin resistance in animal studies

5.Involvement in exercise adaptation, cellular stress responses, and aging-related processes

Its mechanism of action is believed to be associated with the accumulation of AICAR and subsequent activation of AMPK signaling.

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Q&A

Q: When can I receive the package?

A: It will be shipped as soon as possible after payment, and the shipping time is generally 7 to 15 days.

Q: What is the minimum amount I can order? A: The minimum quantity we can order is 1 box, which contains 10 vials. Q:How about the price? Can you make it cheaper?

A:We always take the customer's benefit as the top priority. Price is negotiable under different conditions, we are assuring you to get the most competitive price.

Q: How do i keep the peptides when i receive it ?

A: Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.

Company Profile

HKX is a reliable manufacturer and exporter of peptide raw materials.

We have strong R&D capabilities and advanced production facilities. Our products cover various synthetic peptides and related raw materials, which are widely used in scientific research and pharmaceutical development. Every batch of goods undergoes rigorous laboratory testing to meet international quality standards.

We have years of international trade experience and a complete logistics system. Neutral packaging is used for all goods to comply with international shipping regulations. We provide flexible order solutions for customers, from small trial orders to large bulk purchases.

Sticking to the philosophy of Quality Priority and Customer Oriented, we sincerely welcome customers from all over the world to negotiate business and create win-win cooperation.

Why Choose Us

·Ultra-High Purity Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.

·Accurate Dosing & Consistency Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.

·Endotoxin-Free & Sterile Processing Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

·Retail and bulk orders are accepted.

·Neutral packaging with full sealing for safe international shipping.

·Fast dispatch within 1-3 working days after payment confirmation.