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ARA290 (Cibinetide) Product Overview

Product Identification

• CAS Number: 1208243-50-8

• Synonyms: ARA-290, pHBSP (Pyroglutamate Helix B Surface Peptide)

• Molecular Formula: C₅₁H₈₄N₁₆O₂₁

• Molecular Weight: 1257.3 g/mol

• Sequence: Pyroglutamic acid-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr-EQLERALNSS-OH) 145.

Introduction

Cibinetide (ARA290) is a synthetic, nonerythropoietic 11-mer peptide engineered from the helix B surface domain of erythropoietin (EPO). It retains EPO's tissue-protective and anti-inflammatory properties but lacks hematopoietic activity, making it ideal for neuroprotective and immunomodulatory research 147.

Mechanism of Action

ARA290 selectively activates the innate repair receptor (IRR), a heterodimer of the EPO receptor and CD131 (β-common receptor). This receptor is upregulated in injured tissues and triggers:

• Anti-inflammatory responses: Inhibits apoptosis and cell death signals.

• Neuroprotection: Modulates pain signaling via immune-nociception integration, particularly through TRPV1 channel targeting.

• Tissue regeneration: Enhances endothelial cell proliferation and migration

• Key Research Applications

  1. Neuropathic Pain Relief:

     • Provides long-term analgesia by suppressing spinal microglia activation and reducing neuroinflammation in peripheral nerve injury models 18.

  2. Diabetes & Autoimmune Disorders:

     • Improves glucose tolerance in diabetic models and attenuates experimental autoimmune encephalomyelitis (EAE) severity 78.

  3. Organ Protection:

     • Shields kidneys from cisplatin-induced toxicity and enhances human islet survival in transplantation stress 812.

  4. Vascular Repair:

     • Boosts blood flow recovery in ischemic tissues by promoting endothelial colony-forming cell (ECFC) activity 712.

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  Physicochemical Properties

  • Appearance: White to off-white lyophilized powder.

  • Purity: ≥95% (HPLC-verified).

  • Solubility: >50 mg/mL in water; soluble in 0.1 M NaOH (≥50 mg/mL) and DMSO (≥34 mg/mL) 145.

  • Stability: Maintains integrity for >2 years when stored dry, frozen (–20°C), and protected from light 14.

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  Storage & Handling

  • Conditions: Lyophilized powder stored at ≤–20°C in sealed containers. Avoid repeated freeze-thaw cycles.

  • Reconstitution: Use sterile water or 0.1 M NaOH; adjust pH to 8.0 for optimal solubility 

  • Company Introduction

    csxj Technology Co., Ltd.  is an innovative technology enterprise specializing in the field of weight management and metabolic health. We are dedicated to the R&D, production, and supply of high-quality solutions based on cutting-edge biotechnology for the global market, with core expertise in GLP-1-related products and high-purity active ingredients. Leveraging robust scientific capabilities and a stringent quality management system, we consistently deliver safe, efficient weight management and metabolic products and materials to meet diverse client needs. Driven by technological innovation and a customer-centric approach, we collaborate with partners to advance the health industry and empower global users in achieving healthier lifestyles.

    

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  • Product Certificates

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