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2-Bromo-3-hydroxybenzaldehyde CAS 196081-71-7

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CAS No.:

196081-71-7

Packaging:

5g;500g;25g;250mg;1g;10g;100g

Price valid (until):

2025-12-08

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Trader

Location:

China

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Main Products:

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Product Description
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Description

Product Detail

Product Name: 2-Bromo-3-hydroxybenzaldehyde
CAS No.: 196081-71-7
Molecular Formula: C₇H₅BrO₂
Purity: ≥98% (HPLC)
Appearance: Off-white to light yellow crystalline powder

Product Description

2-Bromo-3-hydroxybenzaldehyde (CAS 196081-71-7) is a high-purity, multifunctional organic intermediate with significant importance in pharmaceutical research and development. This compound features a benzaldehyde ring substituted with both bromo and hydroxy functional groups at the 2 and 3 positions, making it a versatile building block for complex molecular synthesis.

As a key pharmaceutical intermediate, it is most notably used in the synthesis of Crisaborole, an active ingredient in topical treatments for atopic dermatitis (eczema). Its unique structure allows for further transformations via various coupling reactions and nucleophilic substitutions, making it invaluable for constructing more complex active pharmaceutical ingredients (APIs).

Key Features & Advantages:

High Purity: Guaranteed ≥98% purity, ensuring consistent and reliable reaction outcomes.
Critical Building Block: Serves as a essential precursor in the synthesis of innovative pharmaceutical compounds.
Multifunctional Reactivity: The presence of bromo, aldehyde, and phenolic hydroxyl groups offers multiple sites for chemical modification.
Strict Quality Control: Every batch undergoes rigorous QC analysis (including HPLC and NMR) to meet the highest industry standards.
Versatile Applications: Primarily used in pharmaceutical R&D, and also has potential applications in agrochemical and material science fields.

Applications:

Pharmaceutical Intermediate: Especially for Crisaborole and other potential dermatological drugs.
Organic Synthesis: A versatile starting material for Suzuki coupling, Buchwald-Hartwig amination, and other metal-catalyzed reactions.
R&D Building Block: Used in the discovery and development of new chemical entities.

Packaging & Storage:

Packaging: Available from grams to kilograms. Custom packaging is available upon request.
Storage: Store in a cool, dry, and well-ventilated place. Keep container tightly closed under inert atmosphere.

Why Choose Our Product?
We are a dedicated supplier of specialty chemicals and pharmaceutical intermediates. We guarantee product quality, competitive pricing, and reliable technical support. Our expertise ensures we can meet your specific requirements for both research and bulk quantities.

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Basic Info

Product Name:

2-Bromo-3-hydroxybenzaldehyde

Other Name:

2-BROMO-3-HYDROXYBENZOIC ACID;B90006;2-Bromo-3-formylphenol;Benzaldehyde, 2-broMo-3-hydroxy-;2-BroMo-3-hydroxybenzaldehyde, 95+%

CAS No.:

196081-71-7

Molecular Formula:

C7H5BrO2

InChIKeys:

OHXPHMPERMIICA-UHFFFAOYSA-N

Molecular Weight:

201.03

Exact Mass:

199.947281

DSSTox ID:

DTXSID30395411

HScode:

2913000090

Categories:

Antibacterials

Characteristics

PSA:

37.3

XLogP3:

1.7

Density:

1.737

Melting Point:

147-148℃

Boiling Point:

252℃

Flash Point:

106℃

Refractive Index:

1.657

See More 2-Bromo-3-hydroxybenzaldehyde Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Bromo-3-hydroxybenzaldehyde Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceutical intermediates,chemical compound,key raw material,synthesis chemicals,api

Location:
Room 906,No.175 jiangtong Road,Baiyun District,Guangzhou Province ,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2025

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A science-driven manufacturer & suppliers of Key Starting Materials (KSMs), pharmaceutical intermediates, and specialty chemicals, purpose-built to support the demanding needs of CDMOs, API manufacturers, and biotech innovators across regulated and semi-regulated markets.

Headquartered in Guangzhou-China, with 25 years of industry experience, our organization is committed to advancing pharmaceutical innovation through reliable, scalable, and customized chemical manufacturing. Our facilities operate under strict GMP guidelines and are equipped with versatile capabilities for handling complex multi-step syntheses and niche chemistries.
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