MSH Release Inhibiting Factor Amide (MIF-1, CAS 2002-44-0) High Purity Peptide Powder for Lab Research with Fast Shipping

MSH Release Inhibiting Factor,amide More Info

MSH Release Inhibiting Factor, amide, also known as Melanostatin or MIF-1, is an endogenous tripeptide with the amino acid sequence Prolyl-Leucyl-Glycinamide (Pro-Leu-Gly-NH₂) . It has a molecular formula of C₁₃H₂₄N₄O₃ and a molecular weight of approximately 284.35 g/mol . Structurally, it is the C-terminal tripeptide fragment derived from the hormone oxytocin through enzymatic cleavage, though it exhibits biological actions that are generally distinct from its parent hormone . This small peptide is stable under desiccated storage at -20°C and demonstrates good solubility in water, DMSO, and .

The primary mechanism of action for MIF-1 involves its function as a potent positive allosteric modulator of dopamine receptors, particularly the D2 and D4 receptor subtypes . Unlike traditional dopamine agonists that directly bind to the receptor's active site, MIF-1 enhances dopamine signaling by binding to a separate site on the receptor, thereby modulating its response to the endogenous neurotransmitter . This unique mechanism has positioned MIF-1 as a valuable research tool for studying dopaminergic pathways and their involvement in various neurological and psychiatric conditions. Additionally, the peptide demonstrates the ability to cross the blood-brain barrier directly from the bloodstream, a critical property for its central nervous system activity .

Beyond its dopaminergic effects, MIF-1 exhibits a diverse range of biological activities that highlight its complex role in neuroendocrine regulation. It functions as an inhibitor of melanocyte-stimulating hormone (MSH) release from the pituitary gland, a property that originally led to its discovery and naming . Furthermore, MIF-1 blocks the physiological and behavioral effects of opioid receptor activation, thereby modulating morphine-induced analgesia and stress-induced analgesia (SIA) . The peptide also potentiates melatonin activity and has been shown to increase brain dopamine levels while antagonizing opioid effects in vivo .

Clinical and preclinical research has explored the therapeutic potential of MIF-1 across several indications. Early studies demonstrated its efficacy in treating human depression, with some reports suggesting greater efficacy and faster onset of action compared to traditional antidepressants . In animal models, administration of MIF-1 at 1 mg/kg via intraperitoneal has been shown to attenuate spiroperidol-induced impairment of striatal dopamine D2 receptor development and to modulate analgesic responses . The peptide is also resistant to rapid metabolism in the bloodstream, contributing to its relatively sustained activity following administration, though it is poorly active orally and is typically administered via in research settings .

The safety and handling profile of MIF-1 is well-characterized for laboratory applications. It is typically stored as a lyophilized powder at -20°C, where it remains stable for extended periods, while solutions stored at -80°C may maintain stability for up to six months . For research use, the peptide can be dissolved in aqueous solutions or DMSO at concentrations of at least 50 mg/mL . As with all research chemicals, standard laboratory precautions should be observed, and the product is strictly intended for research purposes only, not for human therapeutic use

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