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Dibekacin

Dibekacin structure

CAS No:
34493-98-6
Formula:
C18H37N5O8
Chemical Name:
Dibekacin
Synonyms:
D-Streptamine,O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-;O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine;3′,4′-Dideoxykanamycin B;Dibekacin;Dideoxykanamycin B;Debecacin;DKB;51636-19-2;51913-98-5;56590-42-2;58546-43-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

ChEBI: A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring.

Dibekacin is a kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring. It has a role as a protein synthesis inhibitor and an antibacterial agent. It derives from a kanamycin B.|Dibekacin is an aminoglycoside antibiotic marketed in Japan.|Dibekacin is an aminoglycoside antibiotic derived from kanamycin B. Dibekacin is active against bacterial strains that are resistant to kanamycin.|Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.

Dibekacin Basic Attributes

Molecular Weight：

451.52

Exact Mass：

451.52

EC Number：

252-064-6

UNII：

45ZFO9E525

DSSTox ID：

DTXSID2022915

NCI Thesaurus Code：

C79114

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

253.73000

XLogP3：

-5.8

Density：

1.46 g/cm3

Boiling Point：

727.7ºC at 760 mmHg

Toxicity：

LD50 in mice (mg/kg): 61.0-68.0 i.v., 373.0-380.0 i.m. (Komiya)

Specific rotation：

D20 +132° (c = 0.65)

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

3',4' Dideoxykanamycin B

Computed Properties

Molecular Weight:451.5
XLogP3:-5.8
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:6
Exact Mass:451.26421316
Monoisotopic Mass:451.26421316
Topological Polar Surface Area:248
Heavy Atom Count:31
Complexity:579
Defined Atom Stereocenter Count:13
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Dibekacin

CAS No.: 34493-98-6

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