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L-Menthol

L-Menthol structure

CAS No:
2216-51-5
Formula:
C10H20O
Chemical Name:
L-Menthol
Synonyms:
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L-Meng alcohol Natural menthol Menthol (L);DL-Menthol menthol crystal extract
Categories:
Biochemical Engineering > Chinese Herbs

Description

white to light yellow crystal powde

ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer.

Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate.

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.]

L-Menthol Basic Attributes

Molecular Weight：

156.27

BRN：

1902293

EC Number：

218-690-9

TSCA：

TSCA listed

Color/Form：

Colorless to white

HScode：

29061100

Characteristics

Density：

0.89 g/mL at 25 °C (lit.)

Melting Point：

41-45 °C (lit.)

Boiling Point：

212 °C (lit.)

Refractive Index：

1.46

Water Solubility：

insoluble

Vapor Pressure：

0.8 mm Hg ( 20 °C)

Toxicity：

LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Flammability characteristics：

Non flammable

Odor：

at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty

PKA：

15.30±0.60(Predicted)

Henrys Law Constant：

6.6×10-1mol/(m3Pa) at 25℃, HSDB (2015)

Critical Temperature & Pressure：

Store below +30°C.

Safety Information

wgk germany：

hazard class code：

safety instructions：

26-39-37/39-36

RTECS Number：

OT0700000

Hazard Statements：

37/38-41-36/37/38

L-Menthol Use and Manufacturing

(1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.

L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.

Material

Benzaldehyde

Vinyl acetate

Cyclohexanone

Cyclohexane

Triethylamine

Sodium methoxide

Aluminum isopropoxide

Ethanol

Acetic acid

Methanol

Isopropanol

Benzene

tert-Butanol

Ammonia

Downstream Products

Carbon dioxide

Oxalic acid

Formic acid

Drug Function and Efficacy

Cooling and soothing agent with antiseptic and analgesic properties; provides fresh sensation

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

東洋薄荷工業株式会社

Japan
Active
SYMRISE AG

Brazil
Active
Wanhua Chemical Group Nutritional Technology Co., Ltd.

China
Inactive

Recommended Suppliers of L-Menthol

Tianjin Dongfang Import & Export Co., LTD Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Food Additives

High Quality Menthol Crystal Food Grade on sale

Unit Price: $1350-1450 /MT FOB

CAS No.: 2216-51-5

Grade: Food Grade

Content: 99%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

CAS 2216-51-5 Raw Powder USP Standard L-Menthol

Unit Price: $5.1-6.12 /G FOB

CAS No.: 2216-51-5

Grade: Chemical Grade

Content: 99%

Inquiry