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Home > Active Pharmaceutical Ingredients
In the chemical industry, API is Active Pharmaceutical Ingredients, meaning the active ingredients in pharmaceutical products. It is the core substance for producing the intended therapeutic effect. The quality of Active Pharmaceutical Ingredients is critical to the safety and efficacy of the final pharmaceutical product. Therefore, the production of API chemicals involves strict regulatory guidelines and standards, such as GMP (Good Manufacturing Practices) and GLP (Good Laboratory Practices). On ECHEMI, you can select API chemical products on your demand from various active pharmaceutical ingredient manufacturers and distributors.

Active Pharmaceutical Ingredients Suppliers

Buying Active Pharmaceutical Ingredients (APIs) can still be challenging, especially when quality, compliance, and supply stability matter most. On ECHEMI, you can access 743 qualified manufacturers and 380 verified distributors across China, India, the USA, Europe, and other regions. Compare API specifications, review compliance standards, and connect directly with reliable suppliers to support your pharmaceutical production and research needs.
Explore active pharmaceutical ingredients for your specific needs now.
4831 Active Pharmaceutical Ingredients items

Adapalene

CAS No: 106685-40-9

Formula: C28H28O3

Categories: Active Pharmaceutical Ingredients > Specialty Drugs

White Crystalline SolidChEBI: A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.Adapalene, a new class of drugs Naphthoic acid derivatives, was developed by France Galdeama Laboratories Company. It first entered into market in June 1996, under the trade name ''Differin'', mainly used for relieving inflammatory skin lesions, adjusting differentiation of hair follicles, gland epithelial cells, and also acne treatment.More

Isotretinoin

CAS No: 4759-48-2

Formula: C20H28O2

Categories: Active Pharmaceutical Ingredients > Anti-sebum

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.Target: RAR/RXRIsotretinoin has been the most effective and long-lasting drug for the treatment of severe acne for more than 30 years and can achieve long-term remission in 70-80% of patients after a single course. The new evidence-based European S3-guideline recommends the usMore

Cetirizine hydrochloride

CAS No: 83881-52-1

Formula: C21H25ClN2O3.2ClH

Categories: Active Pharmaceutical Ingredients > Antiallergic Drugs

Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value:Target: Histamine H1 receptorCetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. fMore

Rosuvastatin calcium

CAS No: 147098-20-2

Formula: C22H28FN3O6S.1/2Ca

Categories: Active Pharmaceutical Ingredients > Circulatory System Drugs

White to Off-White Crystalline SolidChEBI: An organic calcium salt that is the hemicalcium salt of rosuvastatin.Rosuvastatin, one of the two new statins launched for the treatment of hypercholesterolemia, has high hepato-selectivity and more potent inhibitory effect on HMG-CoA reductase than the previously marketed statins. In rat hepatocytes, it inhibits cholesterol biosynthesis with an IC50 of 1.12 nM, which is ~100-fold higher potency than pravastatin. Rosuvastatin is synthesizMore

Phenothiazine

CAS No: 92-84-2

Formula: C12H9NS

Categories: Active Pharmaceutical Ingredients > Antiparasitic Drugs

It is clean gray-green powder with the melting point of 185.5 ℃, boiling point of 371 ℃, 290 ℃ (5.33kPa). It is insoluble in petroleum ether, chloroform and water, and soluble in ether and hot acetic acid. It will be oxidized upon exposure to light in the air. Phenothiazine is a greenish-yellow to greenish-gray crystalline substance. Slight odor and taste. yellow or pale green powderMore

Norfloxacin

CAS No: 70458-96-7

Formula: C16H18FN3O3

Categories: Active Pharmaceutical Ingredients > Inhibitor Drugs

It is white to light yellow crystalline powder. It is odorless with slightly bitter taste. Upon exposure to the air, it can easily absorb moisture to form a hemihydrate. Its color will be deepened upon light. Solubility (mg/m1) in 25 ℃: 0.28 in water, 0.98 in methanol, 1.9 in ethanol, 5.1 in acetone, 5.5 in chloroform, 0.01 in diethyl ether, 0.15 in benzene, 0.94 in ethyl acetate, 5.1 in octanol, and 340 in glacial acetic acid. It is easily soluble in acidic or alkaline solution and slightly soMore

Estriol

CAS No: 50-27-1

Formula: C18H24O3

Categories: Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.Target: Estrogen Receptor/ERRA recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity [1]. In mPTEN+/- mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol alsoMore

Doxorubicin

CAS No: 23214-92-8

Formula: C27H29NO11

Categories: Active Pharmaceutical Ingredients > Antineoplastics

Doxorubicin is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair. More

Glibenclamide

CAS No: 10238-21-8

Formula: C23H28ClN3O5S

Categories: Active Pharmaceutical Ingredients > Hormones and the Endocrine System

White or almost white, crystalline powderChEBI: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.Glyburide (glibenclamide) is 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide; this compound can also be named asthe urea—see preceding discussion (Diabeta, Glynase,generic). Some tablet formulations contain micronized drug(formerly Micronase, now only generic). Combinations areaMore

(±)-Voriconazole

CAS No: 188416-29-7

Formula: C16H14F3N5O

Categories: Active Pharmaceutical Ingredients > Inhibitor Drugs

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Phenoxyethanol

CAS No: 122-99-6

Formula: C8H10O2

Categories: Active Pharmaceutical Ingredients > Cosmetic Preservative

clear colorless liquid Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.Colorless liMore

Candesartan cilexetil

CAS No: 145040-37-5

Formula: C33H34N6O6

Categories: Active Pharmaceutical Ingredients > Circulatory System Drugs

White SolidCandesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanol but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II tMore

Sorafenib

CAS No: 284461-73-0

Formula: C21H16ClF3N4O3

Categories: Active Pharmaceutical Ingredients > Circulatory System Drugs

Sorafenib (Bay 43-9006) is a potent multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. More

Miconazole nitrate

CAS No: 22832-87-7

Formula: C18H14Cl4N2O.HNO3

Categories: Active Pharmaceutical Ingredients > Antimicrobials

Miconazole Nitrate is an imidazole antifungal agent.Target: AntifungalMiconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. It can also be used against certain species of Leishmania protozoa which are a type of unicellular parasite that also contain ergosterol in their cell meMore

Huperzine A

CAS No: 120786-18-7

Formula: C15H18N2O

Categories: Active Pharmaceutical Ingredients > Nervous System Drugs

Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might beMore

Chromium trioxide

CAS No: 1333-82-0

Formula: CrO3

Categories: Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

CrO3: Dark-red, odorless flakes or powder. [Note: Often used in an aqueous solution (H2CrO4).]More

Donepezil

CAS No: 120014-06-4

Formula: C24H29NO3

Categories: Active Pharmaceutical Ingredients > Nervous System Drugs

ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approxiMore

Active Pharmaceutical Ingredients Market

Market report will help you efficiently source API chemicals! ECHEMI can provide export and import data of API products you need to monitor and analyze the API market!
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Frequently Asked Questions

Are APIs safe to store and transport?

APIs must be handled according to regulatory and safety guidelines. Proper storage conditions, protective equipment, and transportation protocols are required to maintain stability and prevent contamination or hazards.

What industries use APIs?

APIs are widely used in pharmaceutical, veterinary, nutraceutical, and chemical research industries. They are essential for manufacturing medications, supplements, and experimental formulations.

How can I buy active pharmaceutical ingredients in bulk?

You can find certified API manufacturers and traders on ECHEMI. They provide detailed product information, CAS numbers, and safety data sheets (SDS) to ensure safe and reliable bulk purchases.

What are the top selling APIs on ECHEMI?

The top selling APIs on ECHEMI include Veterinary Raw Materials, Anesthetic Agents, Antiallergic Drugs, Feed Additives, Hormones and Endocrine Drugs, Digestive System Drugs, Vitamins and Minerals, Synthetic Anti-infective Drugs, Respiratory Drugs, and other chemical drugs.

What are active pharmaceutical ingredients?

Active Pharmaceutical Ingredients, also known as APIs, are the main active ingredients in a pharmaceutical drug to provide the intended therapeutic effect. APIs can be chemically synthesized or obtained from natural sources like plants and animals. After identifying the API, it is combined with other inactive ingredients to create a drug product that can be taken in different forms, such as tablets, capsules or injections.

What are the most common active pharmaceutical ingredients?

Here are some examples of common API chemicals.

1) Paracetamol (Acetaminophen) - a pain reliever and fever reducer

2) Ibuprofen - a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation

3) Aspirin - a medication used to reduce pain, fever, and inflammation and also used as a blood thinner

4) Amoxicillin - an antibiotic used to treat bacterial infections

5) Metformin - an oral medication for type 2 diabetes that lowers blood sugar levels

6) Omeprazole - a proton-pump inhibitor (PPI) used to reduce stomach acid production

7) Atorvastatin - a medication used to lower cholesterol levels in the blood

8) Sertraline - an antidepressant medication belonging to the class of selective serotonin reuptake inhibitors (SSRIs)

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