 Home > News > Market Flash > EU evaluation of safety of pectin lyase produced by transgenic Trichoderma reesei strain RF6199

EU evaluation of safety of pectin lyase produced by transgenic Trichoderma reesei strain RF6199

 foodmate 2022-12-09

On December 8, 2022, the European Food Safety Authority issued an opinion on the safety evaluation of a pectin lyase enzyme.

This food enzyme is known to be produced by the genetically modified Trichoderma reesei strain RF6199. After evaluation, the Panel concluded that the risk of allergic reactions from dietary exposure could not be ruled out under the intended conditions of use, but this likelihood was considered low. Based on the data provided, the Panel concluded that this food enzyme does not pose a safety problem under the intended conditions of use. Some of the original articles are reported below:

The food enzyme pectin lyase ((1-4)-6-O-methyl-α-D-galacturo nan lyase; EC 4.2.2.10) is produced with the genetically modified Trichoderma reesei strain RF6199 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. It is intended to be used in six manufacturing processes: fruit and vegetable processing for juice production, fruit and vegetable processing for fruit brandies, fruit and vegetable processing for products other than juices, wine and wine vinegar production, refined and unrefined sugar production and coffee bean demucilation. Foods obtained from fruit processing for fruit brandies and coffee bean demucilation, as well as refined sugars, were excluded from dietary exposure estimation. For the remaining four processes, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.2 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,000 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, results in a margin of exposure of at least 5,000. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood of such reactions is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

pectinlyase

 Disclaimer: ECHEMI reserves the right of final explanation and revision for all the information.

Japan is open for comments on the health impact evaluation of α-amylase produced with JPBL013

The European Union evaluates the safety of a food enzyme, phytepsin

Comment

Comment

You May Interested In

Research Grade RT Retatrutide Peptide Raw Material 99% Purity Lab Experiment Sample Only

$15/MT FOB

Silk Road Trading Co.,Ltd

GHK-Cu Copper Peptide Lyophilized Powder Cosmetic Formulation Raw Material Factory

$18/BOU FOB

Silk Road Trading Co.,Ltd

buy Factory Supply Retatrutide Peptide Lyophilized Vial 20mg Custom Lab Research Cosmetic Raw Material Bulk Wholesale With Independent Test

Factory Supply Retatrutide Peptide Lyophilized Vial 20mg Custom Lab Research Cosmetic Raw Material Bulk Wholesale With Independent Test

$55/BOU FOB

Silk Road Trading Co.,Ltd

buy Lab Use Only Melanotan II MT-2 10mg Lyophilized Peptide Raw Material With Batch COA





Popular Tags

Daily Morning Brief

2026-09-10

Wanhuaâs Hungary BorsodChem restarts MDI, TDI output

BP North Sea Assets Draw Interest From Suitors Including Adura, NEO Next+

Aarti Industries Launches New Multipurpose Plant, Calcium Chloride, PEDA Output

Loop Industries Names Jeff Geygan as Board Chairman

Baker Hughes Raises Annual Forecasts After Chart Acquisition

View All

Trade Alert

Delivering the latest product trends and industry news straight to your inbox.
(We'll never share your email address with a third-party.)

Recommend Reading

Hot Searches: potassium ocide; polyurethane melting point; white mineral oil; medetomidine for sale; ammonium solfate; ethyl acetate msds; 9 me bc for sale; ldpe resin price asia 2025 english; buy amino acid derivatives online; retatrutide buy online; creatine monohydrate wikipedia; aluminum sulfate purchase



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.

EU evaluation of safety of pectin lyase produced by transgenic Trichoderma reesei strain RF6199

Japan is open for comments on the health impact evaluation of α-amylase produced with JPBL013

The European Union evaluates the safety of a food enzyme, phytepsin

You May Interested In

Research Grade RT Retatrutide Peptide Raw Material 99% Purity Lab Experiment Sample Only

GHK-Cu Copper Peptide Lyophilized Powder Cosmetic Formulation Raw Material Factory

Factory Supply Retatrutide Peptide Lyophilized Vial 20mg Custom Lab Research Cosmetic Raw Material Bulk Wholesale With Independent Test

Lab Use Only Melanotan II MT-2 10mg Lyophilized Peptide Raw Material With Batch COA

β-Nicotinamide Adenine Dinucleotide High Quality NAD+ CAS 53-84-9 Exclusive Production Factory CAS NO.53-84-9

Scyllo-Inositol 99% CAS No 488-59-5 Manufacturer

Related News

Recommend Reading