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Suxibuzone

Suxibuzone structure

CAS No:
27470-51-5
Formula:
C24H26N2O6
Chemical Name:
Suxibuzone
Synonyms:
Butanedioic acid,1-[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester;Succinic acid,monoester with 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione;Butanedioic acid,mono[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester;3,5-Pyrazolidinedione,4-butyl-4-(hydroxymethyl)-1,2-diphenyl-,hydrogen succinate (ester);4-Hydroxymethylbutazolidine hemisuccinate;Suxibuzone;AE 17;Flogos;Solurol;Calibene;Danilon;Suxibutazone
Categories:
Analytical Chemistry > Standard

Description

Suxibuzone is a drug used for joint and muscular pain, is a prodrug of the non steroidal anti inflammatory drug Phenylbutazone.

Suxibuzone is a pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses. It has a role as a prodrug, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a non-narcotic analgesic and a peripheral nervous system drug. It is a member of pyrazolidines, a monocarboxylic acid and a hemisuccinate.

Suxibuzone Basic Attributes

Molecular Weight：

438.47

Exact Mass：

438.47

EC Number：

248-477-6

UNII：

86TDZ5WP2B

NSC Number：

757866

DSSTox ID：

DTXSID6021296

ATC Code：

M - Musculo-skeletal system

HScode：

2933990090

Characteristics

PSA：

104.22000

XLogP3：

3.69600

Density：

1.265g/cm3

Melting Point：

126-127 °C

Boiling Point：

590.1ºC at 760 mmHg

Flash Point：

310.7ºC

Refractive Index：

1.579

Water Solubility：

Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent), practically insoluble in cyclohexane.

Vapor Pressure：

9.05E-15mmHg at 25°C

Toxicity：

LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973)

Collision Cross Section：

199.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

WM9640000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302-H312-H332

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

1,2-diphenyl-4-n-butyl-4-hydroxymethyl-3,5-dioxopyrazolidine hemisuccinate

Suxibuzone Use and Manufacturing

Uses

analgesic, antipyretic, antiinflammatory

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:438.5
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:438.17908655
Monoisotopic Mass:438.17908655
Topological Polar Surface Area:104
Heavy Atom Count:32
Complexity:661
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Suxibuzone

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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CAS No.: 27470-51-5

Content: 99.00%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

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Suxibuzone

CAS No.: 27470-51-5

Grade: Pharmaceutical Grade

Content: 99%

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