5-Bromo-6-methyl-2-pyridinamine
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5-Bromo-6-methyl-2-pyridinamine
structure -
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CAS No:
42753-71-9
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Formula:
C6H7BrN2
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Chemical Name:
5-Bromo-6-methyl-2-pyridinamine
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Synonyms:
2-Pyridinamine,5-bromo-6-methyl-;5-Bromo-6-methyl-2-pyridinamine;2-Amino-5-bromo-6-methylpyridine;6-Amino-3-bromo-2-picoline;6-Amino-3-bromo-2-methylpyridine;3-Bromo-2-methylpyridin-6-amine;5-Bromo-6-methylpyridin-2-amine;5-Bromo-6-methyl-2-aminopyridine;2-Amino-6-methyl-5-bromopyridine
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CAS No:
5-Bromo-6-methyl-2-pyridinamine Basic Attributes
187.04
187.04
114140
255-927-5
DTXSID8068414
29333999
Characteristics
38.9
1.6
White to off-white Fluffy Powder
1.6±0.1 g/cm3
79-84 °C(lit.)
234.3°C at 760 mmHg
95.5±25.9 °C
1.617
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38
26-36-26/37/39
Xi
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Bromo-6-methyl-2-pyridinamine Use and Manufacturing
General procedure: To a mixture of 2-aminopyridine (0.5 mmol, 1 equiv), p-TSA (0.4 mmol, 0.8 equiv), 1-butylpyridinium bromide (1.5 mmol, 3 equiv) in a 50 mL Schlenk tube were added 1, 2-dimethoxyethane (2 mL) under air. Then HTo a 2L flask was added 2-amino-6-methylpyridine (50 g, 0.462 mole) and DCM (1.0 L) and the solution was cooled to -5 Step 1 The 6-Methylpyridin-2-amine (1.08g, 10mmol) dissolved in glacial acetic acid (20 ml) in, bromine is added for (1.6g, 10mmol), 25 °C reaction 16 hours. Water (50 ml), ethyl acetate extraction (150 ml × 2), combined organic phase, saturated salt water washing, dry anhydrous sodium sulfate, concentrated under vacuum, the crude product by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) purification, to obtain the title compound (800 mg, yield 42.8percent).A solution of 6-methylpyridin-2-amine (5 g 46.2 mmol) in MeOH (20 mL) stirred under N
2-Pyridinamine, 5-bromo-6-methyl-: INACTIVE
Computed Properties
Molecular Weight:187.04
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:185.97926
Monoisotopic Mass:185.97926
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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