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Fenspiride

Fenspiride structure

CAS No:
5053-06-5
Formula:
C15H20N2O2
Chemical Name:
Fenspiride
Synonyms:
1-Oxa-3,8-diazaspiro[4.5]decan-2-one,8-(2-phenylethyl)-;1-Oxa-3,8-diazaspiro[4.5]decan-2-one,8-phenethyl-;8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Fenspiride;Respiride;DESP
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.|Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.

Fenspiride Basic Attributes

Molecular Weight：

260.34

Exact Mass：

260.33

EC Number：

225-751-3

UNII：

S983QC7HKM

DSSTox ID：

DTXSID4023048

ATC Code：

R - Respiratory system

HScode：

2934999090

Characteristics

PSA：

41.6

XLogP3：

1.91

Density：

1.2±0.1 g/cm3

Melting Point：

232-233

Boiling Point：

126-127 °C @ Press: 2 Torr

Flash Point：

200.7±31.5 °C

Refractive Index：

1.609

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

MeSH Entry Terms：

3612 S

Fenspiride Use and Manufacturing

Uses

Bronchodilator;anti-adrenergic (β-receptor).Fenspiro is a serotonin antagonist. Its effect of expanding bronchial smooth muscle is between isoproterenol and theophylline. It also has a smooth airway and eliminates air resistance in the lungs. It also has antitussive, antipyretic, Analgesic and anti-inflammatory effects, antipyretic and analgesic effect is better than aminopyrine, anti-inflammatory effect is stronger than Bao Taisong.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:260.33
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:260.152477885
Monoisotopic Mass:260.152477885
Topological Polar Surface Area:41.6
Heavy Atom Count:19
Complexity:318
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 5053-06-5

Grade: Different Grade

Content: 99.9%

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